Tmprss13 MGI Mouse Gene Detail - MGI:2682935 - transmembrane protease, serine 13

Symbol

Tmprss13
Name

transmembrane protease, serine 13

Feature Type

protein coding gene
IDs

MGI:2682935
NCBI Gene: 214531
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr9:45230398-45258879 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.84 cM
Mapping Data

2 experiments

SNPs within 2kb

1084 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2682935	protein coding gene	Chr9:45230286-45258879 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034736	protein coding gene	Chr9:43870202-43900345 (+)
A/J	MGP_AJ_G0034717	protein coding gene	Chr9:42648920-42677694 (+)
AKR/J	MGP_AKRJ_G0034644	protein coding gene	Chr9:43523904-43552909 (+)
BALB/cJ	MGP_BALBcJ_G0034708	protein coding gene	Chr9:42378304-42407182 (+)
C3H/HeJ	MGP_C3HHeJ_G0034419	protein coding gene	Chr9:43982192-44011673 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035229	protein coding gene	Chr9:45160825-45189154 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032143	protein coding gene	Chr9:42197756-42226591 (+)
CAST/EiJ	MGP_CASTEiJ_G0033741	protein coding gene	Chr9:43841629-43870366 (+)
CBA/J	MGP_CBAJ_G0034391	protein coding gene	Chr9:46801576-46835714 (+)
DBA/2J	MGP_DBA2J_G0034550	protein coding gene	Chr9:42533677-42562178 (+)
FVB/NJ	MGP_FVBNJ_G0034491	protein coding gene	Chr9:41793402-41823836 (+)
LP/J	MGP_LPJ_G0034631	protein coding gene	Chr9:44181555-44210211 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034535	protein coding gene	Chr9:48619268-48651824 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035250	protein coding gene	Chr9:43442452-43471055 (+)
PWK/PhJ	MGP_PWKPhJ_G0033446	protein coding gene	Chr9:42423149-42452340 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033282	protein coding gene	Chr9:43745516-43775661 (+)
WSB/EiJ	MGP_WSBEiJ_G0033854	protein coding gene	Chr9:43475267-43505088 (+)

Human Ortholog

TMPRSS13, transmembrane serine protease 13

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMPRSS13, transmembrane serine protease 13
Synonyms

MSP, MSPL, MSPS, TMPRSS11
Links

HGNC:29808

NCBI Gene ID: 84000

neXtProt AC: NX_Q9BYE2

UniProt: Q9BYE2
Chr Location

11q23.3; chr11:117900641-117929459 (-) GRCh38

MGI Vertebrate Homology

Tmprss13 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TMPRSS13
Protein SuperFamily

TMPRSS13
Gene Tree

Tmprss13

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Phenotype Summary

6 phenotypes from 1 allele in 2 genetic backgrounds
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

1
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and outwardly healthy but exhibit abnormal stratum corneum formation leading to impaired skin barrier function, as measured by the transepidermal fluid loss rate in newborn pups.

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

786
Tissues

56
cDNA Data

6
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmprss13

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All Sequences

37
RefSeq

6
UniProt

2
CCDS

CCDS23132.1

Ensembl

ENSMUSG00000037129 (Evidence)
NCBI Gene

214531

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037129	Ensembl Gene Model \| MGI Sequence Detail	28482	C57BL/6J	± kb
transcript	ENSMUST00000034597	Ensembl \| MGI Sequence Detail	3245	Not Applicable
polypeptide	ENSMUSP00000034597	Ensembl \| MGI Sequence Detail	548	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016455 transmembrane protease serine 13

(term hierarchy)
EC

3.4.21.-
InterPro Domains

IPR002172 Low-density lipoprotein (LDL) receptor class A repeat

IPR001314 Peptidase S1A, chymotrypsin family

IPR017327 Peptidase S1A, TMPRSS13

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

IPR001254 Serine proteases, trypsin domain

IPR018114 Serine proteases, trypsin family, histidine active site

IPR033116 Serine proteases, trypsin family, serine active site

IPR001190 SRCR domain

IPR017448 SRCR-like domain

IPR036772 SRCR-like domain superfamily
GlyGen

Q5U405 4 sites

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All nucleic 8

cDNA 6

Primer pair 2

Microarray probesets 3

Summaries

All 26

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 4
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:298935 Murray AS, et al., The cell-surface anchored serine protease TMPRSS13 promotes breast cancer progression and resistance to chemotherapy. Oncogene. 2020 Oct;39(41):6421-6436

TSS for Tmprss13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84762	Chr9:45230280-45230317 (+)	-99 bp
Tssr84763	Chr9:45230319-45230360 (+)	-58 bp
Tssr84764	Chr9:45230370-45230384 (+)	-21 bp
Tssr84765	Chr9:45239792-45239806 (+)	9,401 bp
Tssr84766	Chr9:45258102-45258105 (+)	27,706 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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