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Fnip2 Gene Detail
Summary
  • Symbol
    Fnip2
  • Name
    folliculin interacting protein 2
  • Synonyms
    D630023B12Rik, mKIAA1450
  • Feature Type
    protein coding gene
  • IDs
    MGI:2683054
    NCBI Gene: 329679
  • Alliance
    gene page
  • Transcription Start Sites
    37 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:79363281-79475103 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 34.91 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3504 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2683054
 protein coding gene Chr3:79363281-79475458 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027312
 protein coding gene Chr3:79143387-79264336 (-)
A/J MGP_AJ_G0027274
 protein coding gene Chr3:76569116-76682566 (-)
AKR/J MGP_AKRJ_G0027242
 protein coding gene Chr3:78326784-78451965 (-)
BALB/cJ MGP_BALBcJ_G0027285
 protein coding gene Chr3:76596827-76710444 (-)
C3H/HeJ MGP_C3HHeJ_G0027029
 protein coding gene Chr3:78660219-78777898 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027731
 protein coding gene Chr3:82171438-82287744 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025084
 protein coding gene Chr3:72211287-72320430 (-)
CAST/EiJ MGP_CASTEiJ_G0026476
 protein coding gene Chr3:78717459-78839322 (-)
CBA/J MGP_CBAJ_G0027004
 protein coding gene Chr3:84888115-85011642 (-)
DBA/2J MGP_DBA2J_G0027140
 protein coding gene Chr3:76126509-76237747 (-)
FVB/NJ MGP_FVBNJ_G0027108
 protein coding gene Chr3:74465907-74579279 (-)
LP/J MGP_LPJ_G0027248
 protein coding gene Chr3:80121008-80242085 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027127
 protein coding gene Chr3:91149089-91264314 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027789
 protein coding gene Chr3:78165911-78286262 (-)
PWK/PhJ MGP_PWKPhJ_G0026210
 protein coding gene Chr3:75880287-75995187 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026026
 protein coding gene Chr3:77311050-77427396 (-)
WSB/EiJ MGP_WSBEiJ_G0026554
 protein coding gene Chr3:78491248-78611203 (-)



Homology
more
  • Human Ortholog
    FNIP2, folliculin interacting protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FNIP2, folliculin interacting protein 2
  • Synonyms
    FNIPL, MAPO1
  • Links
    NCBI Gene ID: 57600
    neXtProt AC: NX_Q9P278
    UniProt: Q9P278

  • Chr Location
    4q32.1; chr4:158769026-158908050 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have normal lifespans. Mice with combined loss of this gene and a single null allele of Fnip1 develop kidney cancer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    28
  • cDNA Data
    51
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061175 Ensembl Gene Model | MGI Sequence Detail 111823 C57BL/6J ±  kb
    transcript ENSMUST00000133154 Ensembl | MGI Sequence Detail 7299 Not Applicable  
    polypeptide ENSMUSP00000115275 Ensembl | MGI Sequence Detail 1138 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007590 folliculin-interacting protein 2
      (term hierarchy)
    • InterPro Domains
      IPR028086 Folliculin-interacting protein, C-terminal domain
      IPR026156 Folliculin-interacting protein family
      IPR028085 Folliculin-interacting protein, middle domain
      IPR028084 Folliculin-interacting protein, N-terminal domain
      IPR037545 Tripartite DENN domain, FNIP1/2-type
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 51

      Microarray probesets 2
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory