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Mast3 Gene Detail
Summary
  • Symbol
    Mast3
  • Name
    microtubule associated serine/threonine kinase 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2683541
    NCBI Gene: 546071
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71230761-71257681 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    525 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2683541
 protein coding gene Chr8:71230761-71257698 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033727
 protein coding gene Chr8:71081217-71095536 (-)
A/J MGP_AJ_G0033710
 protein coding gene Chr8:68182771-68197074 (-)
AKR/J MGP_AKRJ_G0033635
 protein coding gene Chr8:70139925-70154251 (-)
BALB/cJ MGP_BALBcJ_G0033706
 protein coding gene Chr8:68418710-68433013 (-)
C3H/HeJ MGP_C3HHeJ_G0033416
 protein coding gene Chr8:70783581-70798851 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034223
 protein coding gene Chr8:73758467-73772782 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031167
 protein coding gene Chr8:63000833-63015059 (-)
CAST/EiJ MGP_CASTEiJ_G0032741
 protein coding gene Chr8:70257281-70273064 (-)
CBA/J MGP_CBAJ_G0033394
 protein coding gene Chr8:76423568-76437887 (-)
DBA/2J MGP_DBA2J_G0033548
 protein coding gene Chr8:67901996-67916343 (-)
FVB/NJ MGP_FVBNJ_G0033489
 protein coding gene Chr8:67039813-67067190 (-)
LP/J MGP_LPJ_G0033635
 protein coding gene Chr8:71100919-71115284 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033532
 protein coding gene Chr8:79053755-79068068 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034241
 protein coding gene Chr8:70319342-70333661 (-)
PWK/PhJ MGP_PWKPhJ_G0032449
 protein coding gene Chr8:67198986-67213612 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032285
 protein coding gene Chr8:69283506-69298923 (-)
WSB/EiJ MGP_WSBEiJ_G0032856
 protein coding gene Chr8:70684203-70698477 (-)



Homology
more
  • Human Ortholog
    MAST3, microtubule associated serine/threonine kinase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAST3, microtubule associated serine/threonine kinase 3
  • Synonyms
    DEE108
  • Links
    NCBI Gene ID: 23031
    neXtProt AC: NX_O60307
    UniProt: O60307

  • Chr Location
    19p13.11; chr19:18097778-18151692 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MAST3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    43
  • cDNA Data
    56
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 546071 NCBI Gene Model | MGI Sequence Detail 26921 C57BL/6J ±  kb
    transcript NM_001402974 RefSeq | MGI Sequence Detail 5326 C57BL/6  
    polypeptide Q3U214 UniProt | EBI | MGI Sequence Detail 1321 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000010197 microtubule-associated serine/threonine-protein kinase 3
      (term hierarchy)
    • EC
      2.7.11.1
    • InterPro Domains
      IPR000961 AGC-kinase, C-terminal
      IPR037711 Microtubule-associated serine/threonine-protein kinase, catalytic domain
      IPR015022 Microtubule-associated serine/threonine-protein kinase, pre-PK domain
      IPR023142 Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily
      IPR051067 Na+/H+ exchange regulatory cofactor
      IPR001478 PDZ domain
      IPR041489 PDZ domain 6
      IPR036034 PDZ superfamily
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
      IPR050236 Serine/threonine-protein kinases, AGC
    • GlyGen
      Q3U214 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 56

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory