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Plch1 Gene Detail
Summary
  • Symbol
    Plch1
  • Name
    phospholipase C, eta 1
  • Synonyms
    MGC:57096, PLCeta1, Plcl3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2683547
    NCBI Gene: 269437
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:63603655-63806893 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 30.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    5447 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2683547
 protein coding gene Chr3:63603620-63806929 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027262
 protein coding gene Chr3:62731427-62942727 (-)
A/J MGP_AJ_G0027222
 protein coding gene Chr3:60859322-61063286 (-)
AKR/J MGP_AKRJ_G0027192
 protein coding gene Chr3:62068751-62276865 (-)
BALB/cJ MGP_BALBcJ_G0027235
 protein coding gene Chr3:60632042-60836901 (-)
C3H/HeJ MGP_C3HHeJ_G0026978
 protein coding gene Chr3:62302810-62512449 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027681
 protein coding gene Chr3:65022040-65240856 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025035
 protein coding gene Chr3:57355867-57564312 (-)
CAST/EiJ MGP_CASTEiJ_G0026430
 protein coding gene Chr3:62433742-62646908 (-)
CBA/J MGP_CBAJ_G0026954
 protein coding gene Chr3:67130901-67347234 (-)
DBA/2J MGP_DBA2J_G0027088
 protein coding gene Chr3:60273488-60477993 (-)
FVB/NJ MGP_FVBNJ_G0027056
 protein coding gene Chr3:59079342-59285249 (-)
LP/J MGP_LPJ_G0027199
 protein coding gene Chr3:63569184-63794134 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027073
 protein coding gene Chr3:71611565-71826138 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027739
 protein coding gene Chr3:61995854-62209622 (-)
PWK/PhJ MGP_PWKPhJ_G0026162
 protein coding gene Chr3:59857361-60060704 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025975
 protein coding gene Chr3:61506402-61740044 (-)
WSB/EiJ MGP_WSBEiJ_G0026504
 protein coding gene Chr3:62128225-62344128 (-)



Homology
more
  • Human Ortholog
    PLCH1, phospholipase C eta 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLCH1, phospholipase C eta 1
  • Synonyms
    HPE14, PLC eta 1, PLC-L3, PLCL3
  • Links
    NCBI Gene ID: 23007
    neXtProt AC: NX_Q4KWH8
    UniProt: Q4KWH8

  • Chr Location
    3q25.31; chr3:155375580-155745071 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PLCH1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    824
  • Tissues
    114
  • cDNA Data
    51
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036834 Ensembl Gene Model | MGI Sequence Detail 203239 C57BL/6J ±  kb
transcript ENSMUST00000084105 Ensembl | MGI Sequence Detail 6245 Not Applicable  
polypeptide ENSMUSP00000081122 Ensembl | MGI Sequence Detail 1682 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000012838 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
    (term hierarchy)
  • EC
    3.1.4.11
  • InterPro Domains
    IPR028392 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1, catalytic domain
    IPR046972 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1, EF-hand motif
    IPR000008 C2 domain
    IPR035892 C2 domain superfamily
    IPR018247 EF-Hand 1, calcium-binding site
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
    IPR011993 PH-like domain superfamily
    IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
    IPR001192 Phosphoinositide phospholipase C family
    IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
    IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
    IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
    IPR001849 Pleckstrin homology domain
Molecular
Reagents
less
  • All nucleic 51
    cDNA 51

    Microarray probesets 2
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory