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Kcnk12 Gene Detail
Summary
  • Symbol
    Kcnk12
  • Name
    potassium channel, subfamily K, member 12
  • Synonyms
    mntk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684043
    NCBI Gene: 210741
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:88053229-88105422 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 57.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1451 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684043
 protein coding gene Chr17:88049100-88106329 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024106
 protein coding gene Chr17:91181627-91232226 (-)
A/J MGP_AJ_G0024065
 protein coding gene Chr17:88241094-88292037 (-)
AKR/J MGP_AKRJ_G0024034
 protein coding gene Chr17:89710707-89756007 (-)
BALB/cJ MGP_BALBcJ_G0024066
 protein coding gene Chr17:88077504-88126897 (-)
C3H/HeJ MGP_C3HHeJ_G0023831
 protein coding gene Chr17:90602536-90653267 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024511
 protein coding gene Chr17:94313609-94365321 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021950
 protein coding gene Chr17:83359859-83405551 (-)
CAST/EiJ MGP_CASTEiJ_G0023311
 protein coding gene Chr17:91434425-91481829 (-)
CBA/J MGP_CBAJ_G0023805
 protein coding gene Chr17:98314766-98369231 (-)
DBA/2J MGP_DBA2J_G0023933
 protein coding gene Chr17:86648223-86693596 (-)
FVB/NJ MGP_FVBNJ_G0023899
 protein coding gene Chr17:86168162-86215093 (-)
LP/J MGP_LPJ_G0024017
 protein coding gene Chr17:91971428-92021016 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023927
 protein coding gene Chr17:98154592-98204876 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024556
 protein coding gene Chr17:90247992-90299198 (-)
PWK/PhJ MGP_PWKPhJ_G0023055
 protein coding gene Chr17:86313965-86362645 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022866
 protein coding gene Chr17:86995664-87040904 (-)
WSB/EiJ MGP_WSBEiJ_G0023376
 protein coding gene Chr17:91077463-91128515 (-)



Homology
more
  • Human Ortholog
    KCNK12, potassium two pore domain channel subfamily K member 12
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNK12, potassium two pore domain channel subfamily K member 12
  • Synonyms
    K2p12.1, THIK-2, THIK2
  • Links
    NCBI Gene ID: 56660
    neXtProt AC: NX_Q9HB15
    UniProt: Q9HB15

  • Chr Location
    2p16.3; chr2:47509290-47570985 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    2
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050138 Ensembl Gene Model | MGI Sequence Detail 52194 C57BL/6J ±  kb
transcript ENSMUST00000055221 Ensembl | MGI Sequence Detail 1972 Not Applicable  
polypeptide ENSMUSP00000053595 Ensembl | MGI Sequence Detail 430 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR013099 Potassium channel domain
    IPR003280 Two pore domain potassium channel
    IPR005410 Two pore domain potassium channel, THIK
  • GlyGen
    Q76M80 1 site, 2 N-linked glycans (1 site)
Molecular
Reagents
less
  • All nucleic 3
    cDNA 2
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 19
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 4
  • Earliest
    J:119550 Harrell MD, et al., Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Physiol Genomics. 2007 Feb 12;28(3):273-83
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory