Tbpl2 MGI Mouse Gene Detail - MGI:2684058 - TATA box binding protein like 2

Symbol

Tbpl2
Name

TATA box binding protein like 2
Synonyms

LOC227606, Trf3

Feature Type

protein coding gene
IDs

MGI:2684058
NCBI Gene: 227606
Alliance

gene page

Sequence Map

Chr2:23961733-23986607 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 16.14 cM
Mapping Data

1 experiment

SNPs within 2kb

631 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684058	protein coding gene	Chr2:23961378-23986607 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025402	protein coding gene	Chr2:21846300-21872154 (-)
A/J	MGP_AJ_G0025380	protein coding gene	Chr2:21004992-21030399 (-)
AKR/J	MGP_AKRJ_G0025349	protein coding gene	Chr2:21703079-21728002 (-)
BALB/cJ	MGP_BALBcJ_G0025375	protein coding gene	Chr2:21117435-21147407 (-)
C3H/HeJ	MGP_C3HHeJ_G0025136	protein coding gene	Chr2:21654465-21681578 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025819	protein coding gene	Chr2:22522992-22551773 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023231	protein coding gene	Chr2:19967970-19987107 (-)
CAST/EiJ	MGP_CASTEiJ_G0024599	protein coding gene	Chr2:21527532-21552964 (-)
CBA/J	MGP_CBAJ_G0025114	protein coding gene	Chr2:23361923-23391853 (-)
DBA/2J	MGP_DBA2J_G0025247	protein coding gene	Chr2:20883774-20909211 (-)
FVB/NJ	MGP_FVBNJ_G0025209	protein coding gene	Chr2:20611510-20636289 (-)
LP/J	MGP_LPJ_G0025333	protein coding gene	Chr2:21780749-21809008 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025240	protein coding gene	Chr2:23543510-23569261 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025878	protein coding gene	Chr2:21644994-21672757 (-)
PWK/PhJ	MGP_PWKPhJ_G0024348	protein coding gene	Chr2:20672562-20697676 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024148	protein coding gene	Chr2:21768233-21794701 (-)
WSB/EiJ	MGP_WSBEiJ_G0024669	protein coding gene	Chr2:21731013-21759000 (-)

Human Ortholog

TBPL2, TATA-box binding protein like 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TBPL2, TATA-box binding protein like 2
Synonyms

TBP2, TRF3
Links

HGNC:19841

NCBI Gene ID: 387332

neXtProt AC: NX_Q6SJ96

UniProt: Q6SJ96
Chr Location

14q22.3

MGI Vertebrate Homology

Tbpl2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TBPL2
Gene Tree

Tbpl2

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Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Female mice homozygous for a knock-out allele exhibit infertility due to impaired folliculogenesis before or during secondary follicle development.

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All GO Annotations

10
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

875
Tissues

130
cDNA Data

4
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

5
UniProt

3
CCDS

CCDS15732.1

Ensembl

ENSMUSG00000061809 (Evidence)
NCBI Gene

227606

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061809	Ensembl Gene Model \| MGI Sequence Detail	24875	C57BL/6J	± kb
transcript	ENSMUST00000080453	Ensembl \| MGI Sequence Detail	1379	Not Applicable
polypeptide	ENSMUSP00000079309	Ensembl \| MGI Sequence Detail	350	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016139 TATA box-binding protein-like 2

(term hierarchy)
InterPro Domains

IPR000814 TATA-box binding protein

IPR030491 TATA-box binding protein, conserved site

IPR033710 TATA-box binding protein, eukaryotic

IPR012295 TBP domain superfamily

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All nucleic 8

cDNA 5

Primer pair 3

Microarray probesets 1

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MGI:2685194

Summaries

All 31

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 6
Earliest

J:87288 Persengiev SP, et al., TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14887-91
Latest

J:302834 Yu C, et al., TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage. Nat Commun. 2020 Dec 22;11(1):6439

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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