Tg(Fabp1-Ccnd1)4Rdb
Transgene Detail

Summary

• Symbol: Tg(Fabp1-Ccnd1)4Rdb
• Name: transgene insertion 4, R Daniel Beauchamp
• MGI ID: MGI:2684226
• Transgene: Tg(Fabp1-Ccnd1)4Rdb Location: unknown
• Alliance: Tg(Fabp1-Ccnd1)4Rdb page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Fabp1-Ccnd1)4Rdb expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ccnd1 (MGI:88313)

• Mutation details: This transgenic construct contains the mouse cyclin D1 gene driven by the rat fatty acid binding protein promoter. Transgenic mice overexpress cyclin D1 in the liver and epithelial cells of the small intestine and colon. A lower level of expression occurs in the kidneys. This line carries 20-fold more transgene copies than the F2 line, which itself carries multiple transgene copies. (J:70394)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Fabp1-Ccnd1)4Rdb

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:70394 Deane NG, et al., Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice. Cancer Res. 2001 Jul 15;61(14):5389-95
• All: 2 reference(s)