Togaram1 MGI Mouse Gene Detail - MGI:2684313 - TOG array regulator of axonemal microtubules 1

Symbol

Togaram1
Name

TOG array regulator of axonemal microtubules 1
Synonyms

A430041B07Rik, Fam179b

Feature Type

protein coding gene
IDs

MGI:2684313
NCBI Gene: 328108
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:65012578-65069347 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 27.21 cM
Mapping Data

2 experiments

SNPs within 2kb

1549 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684313	protein coding gene	Chr12:65012350-65069347 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019777	protein coding gene	Chr12:64441899-64506409 (+)
A/J	MGP_AJ_G0019736	protein coding gene	Chr12:62065311-62126988 (+)
AKR/J	MGP_AKRJ_G0019711	protein coding gene	Chr12:64038110-64099457 (+)
BALB/cJ	MGP_BALBcJ_G0019716	protein coding gene	Chr12:62511238-62569121 (+)
C3H/HeJ	MGP_C3HHeJ_G0019521	protein coding gene	Chr12:64387746-64447357 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020168	protein coding gene	Chr12:66481226-66541791 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017788	protein coding gene	Chr12:59883246-59943179 (+)
CAST/EiJ	MGP_CASTEiJ_G0019073	protein coding gene	Chr12:59089538-59150522 (+)
CBA/J	MGP_CBAJ_G0019490	protein coding gene	Chr12:68903961-68969948 (+)
DBA/2J	MGP_DBA2J_G0019606	protein coding gene	Chr12:61993156-62051195 (+)
FVB/NJ	MGP_FVBNJ_G0019594	protein coding gene	Chr12:61019779-61081764 (+)
LP/J	MGP_LPJ_G0019678	protein coding gene	Chr12:64462434-64527734 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019632	protein coding gene	Chr12:71756260-71832549 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020202	protein coding gene	Chr12:63435763-63493932 (+)
PWK/PhJ	MGP_PWKPhJ_G0018839	protein coding gene	Chr12:56269202-56328345 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018633	protein coding gene	Chr12:57754580-57815570 (+)
WSB/EiJ	MGP_WSBEiJ_G0019124	protein coding gene	Chr12:63959647-64021549 (+)

Human Ortholog

TOGARAM1, TOG array regulator of axonemal microtubules 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TOGARAM1, TOG array regulator of axonemal microtubules 1
Synonyms

FAM179B, JBTS37, KIAA0423
Links

HGNC:19959

NCBI Gene ID: 23116

neXtProt AC: NX_Q9Y4F4

UniProt: Q9Y4F4
Chr Location

14q21.2; chr14:44962190-45074431 (+) GRCh38

MGI Vertebrate Homology

Togaram1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TOGARAM1
Gene Tree

Togaram1

Diseases

1 with human TOGARAM1 associations

				Human Disease	Mouse Models
				Joubert syndrome IDs Joubert syndrome DOID:0050777 ICD10CM:Q04.3 OMIM:PS213300 ORDO:475

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

2
Genomic Mutations

1 involving Togaram1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase togaram1

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All Sequences

68
RefSeq

15
UniProt

8
CCDS

CCDS49075.1, CCDS88345.1

Ensembl

ENSMUSG00000035614 (Evidence)
NCBI Gene

328108

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035614	Ensembl Gene Model \| MGI Sequence Detail	56770	C57BL/6J	± kb
transcript	ENSMUST00000223166	Ensembl \| MGI Sequence Detail	6386	Not Applicable
polypeptide	ENSMUSP00000152616	Ensembl \| MGI Sequence Detail	1826	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000030268 TOG array regulator of axonemal microtubules protein 1

(term hierarchy)
PDB

5DN7
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR034085 TOG domain

IPR048491 XMAP215/Dis1/CLASP, TOG domain

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All nucleic 10

cDNA 10

Microarray probesets 3

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MGI:3039581, MGI:5897572

Summaries

All 35

Gene Ontology 5

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Togaram1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113595	Chr12:65012530-65012549 (+)	-38 bp
Tssr113596	Chr12:65012551-65012562 (+)	-21 bp
Tssr113597	Chr12:65012565-65012584 (+)	-3 bp
Tssr113598	Chr12:65016075-65016082 (+)	3,501 bp
Tssr113599	Chr12:65068593-65068609 (+)	56,023 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24