Vwa2 MGI Mouse Gene Detail - MGI:2684334 - von Willebrand factor A domain containing 2

Symbol

Vwa2
Name

von Willebrand factor A domain containing 2
Synonyms

Amaco

Feature Type

protein coding gene
IDs

MGI:2684334
NCBI Gene: 240675
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:56862848-56900510 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 52.02 cM
Mapping Data

1 experiment

SNPs within 2kb

1332 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684334	protein coding gene	Chr19:56862681-56900510 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025270	protein coding gene	Chr19:57254883-57293971 (+)
A/J	MGP_AJ_G0025246	protein coding gene	Chr19:54425027-54462538 (+)
AKR/J	MGP_AKRJ_G0025215	protein coding gene	Chr19:56145281-56182956 (+)
BALB/cJ	MGP_BALBcJ_G0025241	protein coding gene	Chr19:54501517-54539125 (+)
C3H/HeJ	MGP_C3HHeJ_G0025001	protein coding gene	Chr19:56379556-56417970 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025684	protein coding gene	Chr19:58633717-58673224 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023096	protein coding gene	Chr19:53347413-53387001 (+)
CAST/EiJ	MGP_CASTEiJ_G0024466	protein coding gene	Chr19:56404305-56445544 (+)
CBA/J	MGP_CBAJ_G0024981	protein coding gene	Chr19:61541780-61581686 (+)
DBA/2J	MGP_DBA2J_G0025113	protein coding gene	Chr19:54207783-54245746 (+)
FVB/NJ	MGP_FVBNJ_G0025074	protein coding gene	Chr19:53916091-53954708 (+)
LP/J	MGP_LPJ_G0025199	protein coding gene	Chr19:57109238-57150345 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025107	protein coding gene	Chr19:60801070-60844462 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025742	protein coding gene	Chr19:56350278-56388768 (+)
PWK/PhJ	MGP_PWKPhJ_G0024214	protein coding gene	Chr19:54176503-54214832 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024017	protein coding gene	Chr19:55028811-55066816 (+)
WSB/EiJ	MGP_WSBEiJ_G0024536	protein coding gene	Chr19:56488561-56526026 (+)

Human Ortholog

VWA2, von Willebrand factor A domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VWA2, von Willebrand factor A domain containing 2
Synonyms

AMACO, CCSP-2, CCSP2, NET42
Links

HGNC:24709

NCBI Gene ID: 340706

neXtProt AC: NX_Q5GFL6

UniProt: Q5GFL6
Chr Location

10q25.3; chr10:114239254-114294500 (+) GRCh38

MGI Vertebrate Homology

Vwa2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: VWA2
Gene Tree

Vwa2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

806
Tissues

58
cDNA Data

18
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN vwa2

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All Sequences

40
RefSeq

6
UniProt

2
CCDS

CCDS29923.1

Ensembl

ENSMUSG00000025082 (Evidence)
NCBI Gene

240675

			Length	Strain/Species	Flank
genomic	240675	NCBI Gene Model \| MGI Sequence Detail	37663	C57BL/6J	± kb
transcript	NM_172840	RefSeq \| MGI Sequence Detail	3885	Not Specified
polypeptide	Q70UZ7	UniProt \| EBI \| MGI Sequence Detail	791	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031522 von Willebrand factor A domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR001881 EGF-like calcium-binding domain

IPR013032 EGF-like, conserved site

IPR000742 EGF-like domain

IPR050525 Extracellular Matrix Assembly and Organization

IPR036465 von Willebrand factor A-like domain superfamily

IPR002035 von Willebrand factor, type A
GlyGen

Q70UZ7 1 site

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All nucleic 21

Genomic 2

cDNA 18

Primer pair 1

Microarray probesets 2

Summaries

All 33

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 9
Earliest

J:87179 Sengle G, et al., Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney. J Biol Chem. 2003 Dec 12;278(50):50240-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Vwa2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157220	Chr19:56862473-56862490 (+)	-366 bp
Tssr157221	Chr19:56862835-56862906 (+)	23 bp
Tssr157222	Chr19:56886278-56886290 (+)	23,436 bp
Tssr157223	Chr19:56886300-56886307 (+)	23,456 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24