Mir223 MGI Mouse Gene Detail - MGI:2684360

Symbol

Mir223
Name

microRNA 223
Synonyms

miR-223, Mirn223, mmu-mir-223

Feature Type

miRNA gene
IDs

MGI:2684360
NCBI Gene: 723814
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

ChrX:95286423-95286532 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 42.69 cM
Mapping Data

1 experiment

SNPs within 2kb

70 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684360	miRNA gene	ChrX:95286423-95286532 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0009328	miRNA gene	ChrX:92625769-92625878 (+)
A/J	MGP_AJ_G0009309	miRNA gene	ChrX:92785273-92785382 (+)
AKR/J	MGP_AKRJ_G0009298	miRNA gene	ChrX:95281297-95281406 (+)
BALB/cJ	MGP_BALBcJ_G0009292	miRNA gene	ChrX:91534050-91534159 (+)
C3H/HeJ	MGP_C3HHeJ_G0009232	miRNA gene	ChrX:93112272-93112381 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0009537	miRNA gene	ChrX:95547803-95547912 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0008375	miRNA gene	ChrX:90784156-90784265 (+)
CAST/EiJ	MGP_CASTEiJ_G0009058	miRNA gene	ChrX:77616949-77617058 (+)
CBA/J	MGP_CBAJ_G0009201	miRNA gene	ChrX:98454283-98454392 (+)
DBA/2J	MGP_DBA2J_G0009228	miRNA gene	ChrX:91985626-91985735 (+)
FVB/NJ	MGP_FVBNJ_G0009248	miRNA gene	ChrX:91393335-91393444 (+)
LP/J	MGP_LPJ_G0009326	miRNA gene	ChrX:93629140-93629249 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0009214	miRNA gene	ChrX:102713074-102713183 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0009505	miRNA gene	ChrX:92357139-92357248 (+)
PWK/PhJ	MGP_PWKPhJ_G0008985	miRNA gene	ChrX:75265412-75265521 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0008825	miRNA gene	ChrX:78447259-78447368 (+)
WSB/EiJ	MGP_WSBEiJ_G0009157	miRNA gene	ChrX:91190648-91190757 (+)

Human Ortholog

MIR223, microRNA 223

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR223, microRNA 223
Synonyms

mir-223, MIRN223, miRNA223
Links

HGNC:31603

NCBI Gene ID: 407008
Chr Location

chrX:66018870-66018979 (+) GRCh38

MGI Vertebrate Homology

Mir223 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR223
Gene Tree

Mir223

Diseases

1 with human MIR223 associations

				Human Disease	Mouse Models
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
40 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

3
Targeted

2
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit hypermature granulocytes that are hypersensitive to activating stimuli and display increased fungicidal activity. Mutant mice develop inflammatory lung pathology and show exaggerated tissue destruction afterendotoxin challenge.

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All GO Annotations

13
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

723
Tissues

15
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

22
RefSeq

1

Ensembl

ENSMUSG00000076066 (Evidence)
NCBI Gene

723814

Representative Sequences				Length	Strain/Species	Flank
	genomic	723814	NCBI Gene Model \| MGI Sequence Detail	110	C57BL/6J	± kb
	transcript	NR_029801	RefSeq \| MGI Sequence Detail	110	C57BL/6

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All nucleic 5

Primer pair 1

Other 4

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miRBase

MI0000703

Summaries

All 79

Developmental Gene Expression 8

Gene Ontology 8

Phenotypes 40
Earliest

J:87295 Lim LP, et al., Vertebrate microRNA genes. Science. 2003 Mar 7;299(5612):1540
Latest

J:343295 Chen S, et al., MiR-223-3p promotes genomic stability of hematopoietic progenitors after radiation. Exp Hematol. 2023 Oct 22;

TSS for Mir223:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161563	ChrX:95286512-95286517 (+)	92 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24