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N4bp2 Gene Detail
Summary
  • Symbol
    N4bp2
  • Name
    NEDD4 binding protein 2
  • Synonyms
    B3bp, LOC333789, LOC386488
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684414
    NCBI Gene: 333789
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:65920864-65987451 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 33.80 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1311 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684414
 protein coding gene Chr5:65909462-65987451 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029583
 protein coding gene Chr5:65453770-65526091 (+)
A/J MGP_AJ_G0029551
 protein coding gene Chr5:62994664-63063121 (+)
AKR/J MGP_AKRJ_G0029499
 protein coding gene Chr5:65014238-65088243 (+)
BALB/cJ MGP_BALBcJ_G0029560
 protein coding gene Chr5:63688355-63756992 (+)
C3H/HeJ MGP_C3HHeJ_G0029283
 protein coding gene Chr5:65342165-65412610 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030014
 protein coding gene Chr5:68136142-68210891 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027254
 protein coding gene Chr5:59063051-59125640 (+)
CAST/EiJ MGP_CASTEiJ_G0028691
 protein coding gene Chr5:64438253-64508469 (+)
CBA/J MGP_CBAJ_G0029252
 protein coding gene Chr5:70347241-70429966 (+)
DBA/2J MGP_DBA2J_G0029398
 protein coding gene Chr5:63030295-63099150 (+)
FVB/NJ MGP_FVBNJ_G0029358
 protein coding gene Chr5:62195460-62262430 (+)
LP/J MGP_LPJ_G0029483
 protein coding gene Chr5:65940697-66010063 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029386
 protein coding gene Chr5:73211606-73286880 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030047
 protein coding gene Chr5:64667112-64738240 (+)
PWK/PhJ MGP_PWKPhJ_G0028415
 protein coding gene Chr5:62005752-62074134 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028249
 protein coding gene Chr5:64008620-64080502 (+)
WSB/EiJ MGP_WSBEiJ_G0028771
 protein coding gene Chr5:64887134-64963323 (+)



Homology
more
  • Human Ortholog
    N4BP2, NEDD4 binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    N4BP2, NEDD4 binding protein 2
  • Synonyms
    B3BP
  • Links
    NCBI Gene ID: 55728
    neXtProt AC: NX_Q86UW6
    UniProt: Q86UW6

  • Chr Location
    4p14; chr4:40056797-40190470 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    11
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037795 Ensembl Gene Model | MGI Sequence Detail 66588 C57BL/6J ±  kb
transcript ENSMUST00000201489 Ensembl | MGI Sequence Detail 9055 Not Applicable  
polypeptide ENSMUSP00000143807 Ensembl | MGI Sequence Detail 1678 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR013899 Domain of unknown function DUF1771
    IPR052772 Endonuclease/Polynucleotide Kinase Domain-Containing Protein
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR002625 Smr domain
    IPR036063 Smr domain superfamily
Molecular
Reagents
less
  • All nucleic 13
    cDNA 12
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2685714, MGI:2686637
References
more
  • Summaries
    All 49
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 22
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory