Dcaf15 MGI Mouse Gene Detail - MGI:2684420 - DDB1 and CUL4 associated factor 15

Symbol

Dcaf15
Name

DDB1 and CUL4 associated factor 15
Synonyms

MGC:66593

Feature Type

protein coding gene
IDs

MGI:2684420
NCBI Gene: 212123
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr8:84823701-84831397 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 40.30 cM
Mapping Data

2 experiments

SNPs within 2kb

212 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684420	protein coding gene	Chr8:84823698-84831426 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033854	protein coding gene	Chr8:84968554-84977651 (-)
A/J	MGP_AJ_G0033837	protein coding gene	Chr8:81641507-81648923 (-)
AKR/J	MGP_AKRJ_G0033763	protein coding gene	Chr8:84054001-84061474 (-)
BALB/cJ	MGP_BALBcJ_G0033830	protein coding gene	Chr8:81747829-81755245 (-)
C3H/HeJ	MGP_C3HHeJ_G0033540	protein coding gene	Chr8:84658280-84666807 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034350	protein coding gene	Chr8:88227609-88235307 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031292	protein coding gene	Chr8:75436753-75444105 (-)
CAST/EiJ	MGP_CASTEiJ_G0032870	protein coding gene	Chr8:84081497-84090473 (-)
CBA/J	MGP_CBAJ_G0033516	protein coding gene	Chr8:91341798-91349250 (-)
DBA/2J	MGP_DBA2J_G0033670	protein coding gene	Chr8:81275955-81283814 (-)
FVB/NJ	MGP_FVBNJ_G0033617	protein coding gene	Chr8:80198457-80210759 (-)
LP/J	MGP_LPJ_G0033761	protein coding gene	Chr8:85082322-85089685 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033659	protein coding gene	Chr8:93841875-93850388 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034367	protein coding gene	Chr8:84027776-84035484 (-)
PWK/PhJ	MGP_PWKPhJ_G0032574	protein coding gene	Chr8:80502278-80510477 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032410	protein coding gene	Chr8:82839059-82852105 (-)
WSB/EiJ	MGP_WSBEiJ_G0032983	protein coding gene	Chr8:84442713-84451167 (-)

Human Ortholog

DCAF15, DDB1 and CUL4 associated factor 15

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DCAF15, DDB1 and CUL4 associated factor 15
Synonyms

C19orf72
Links

HGNC:25095

NCBI Gene ID: 90379

neXtProt AC: NX_Q66K64

UniProt: Q66K64
Chr Location

19p13.12; chr19:13952509-13961449 (+) GRCh38

MGI Vertebrate Homology

Dcaf15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DCAF15
Gene Tree

Dcaf15

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Phenotype Summary

33 phenotypes from 1 allele in 1 genetic background
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Gene trapped

2
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Dcaf15
Incidental Mutations

APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

6
cDNA Data

97
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dcaf15

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All Sequences

49
RefSeq

10
UniProt

2
CCDS

CCDS40406.1, CCDS90424.1

Ensembl

ENSMUSG00000037103 (Evidence)
NCBI Gene

212123

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037103	Ensembl Gene Model \| MGI Sequence Detail	7697	C57BL/6J	± kb
transcript	ENSMUST00000041367	Ensembl \| MGI Sequence Detail	2312	Not Applicable
polypeptide	ENSMUSP00000038568	Ensembl \| MGI Sequence Detail	638	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006303 DDB1- and CUL4-associated factor 15

(term hierarchy)
InterPro Domains

IPR038914 DDB1- and CUL4-associated factor 15

IPR047319 DDB1- and CUL4-associated factor 15, C-terminal domain

IPR032734 DDB1- and CUL4-associated factor 15, WD40 repeat-containing domain

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All nucleic 98

cDNA 97

Primer pair 1

Microarray probesets 2

Summaries

All 61

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 36
Earliest

J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
Latest

J:348117 Okuma H, et al., N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on alpha-dystroglycan and prevents muscular dystrophy. Elife. 2023 Feb 1;12

TSS for Dcaf15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr82066	Chr8:84831635-84831646 (-)	-244 bp
Tssr82065	Chr8:84831407-84831422 (-)	-18 bp
Tssr82064	Chr8:84831373-84831388 (-)	16 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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