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Eddm3b Gene Detail
Summary
  • Symbol
    Eddm3b
  • Name
    epididymal protein 3B
  • Synonyms
    Fam12
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684921
    NCBI Gene: 219026
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:51351886-51355248 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    201 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684921
 protein coding gene Chr14:51351883-51355264 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021273
 protein coding gene Chr14:45082126-45085348 (+)
A/J MGP_AJ_G0021228
 protein coding gene Chr14:43729624-43732846 (+)
AKR/J MGP_AKRJ_G0021204
 protein coding gene Chr14:45377425-45380647 (+)
BALB/cJ MGP_BALBcJ_G0021231
 protein coding gene Chr14:43856597-43859819 (+)
C3H/HeJ MGP_C3HHeJ_G0021013
 protein coding gene Chr14:45198716-45201938 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021667
 protein coding gene Chr14:46931053-46934279 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019218
 protein coding gene Chr14:43061092-43064414 (+)
CAST/EiJ MGP_CASTEiJ_G0020536
 protein coding gene Chr14:42270758-42273979 (+)
CBA/J MGP_CBAJ_G0020980
 protein coding gene Chr14:48387400-48390622 (+)
DBA/2J MGP_DBA2J_G0021104
 protein coding gene Chr14:43624111-43627326 (+)
FVB/NJ MGP_FVBNJ_G0021083
 protein coding gene Chr14:43253466-43256681 (+)
LP/J MGP_LPJ_G0021171
 protein coding gene Chr14:45373354-45376576 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021111
 protein coding gene Chr14:47899273-47902488 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021696
 protein coding gene Chr14:44862080-44865302 (+)
PWK/PhJ MGP_PWKPhJ_G0020286
 protein coding gene Chr14:40541189-40544487 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020111
 protein coding gene Chr14:41037069-41040302 (+)
WSB/EiJ MGP_WSBEiJ_G0020589
 protein coding gene Chr14:45062715-45065930 (+)



Homology
more
  • Human Ortholog
    EDDM3A, epididymal protein 3A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EDDM3A, epididymal protein 3A
  • Synonyms
    EP3A, FAM12A, HE3A, HE3-ALPHA, HE3ALPHA, RAM1
  • Links
    NCBI Gene ID: 10876
    neXtProt AC: NX_Q14507
    UniProt: Q14507

  • Chr Location
    14q11.2; chr14:20735946-20748380 (+)  GRCh38
  • Human Ortholog
    EDDM3B, epididymal protein 3B
  • Synonyms
    EP3B, FAM12B, HE3B, HE3-BETA, RAM2
  • Links
    NCBI Gene ID: 64184
    neXtProt AC: NX_P56851
    UniProt: P56851

  • Chr Location
    14q11.2; chr14:20768404-20770948 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice exhibit normal male fertility.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    2
  • cDNA Data
    8
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 219026 NCBI Gene Model | MGI Sequence Detail 3363 C57BL/6J ±  kb
    transcript NM_203508 RefSeq | MGI Sequence Detail 1393 C57BL/6  
    polypeptide NP_987104 RefSeq | MGI Sequence Detail 149 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR042402 Epididymal secretory protein E3-alpha/beta
      IPR023412 Ribonuclease A-domain
      IPR036816 Ribonuclease A-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 1
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 2
      Phenotypes 10
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory