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Kiz Gene Detail
Summary
  • Symbol
    Kiz
  • Name
    kizuna centrosomal protein
  • Synonyms
    Gm114, LOC228730, Ncrna00153, Plk1s1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684960
    NCBI Gene: 228730
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:146697784-146812017 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 72.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2462 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684960
 protein coding gene Chr2:146697743-146812018 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026600
 protein coding gene Chr2:151091172-151224480 (+)
A/J MGP_AJ_G0026564
 protein coding gene Chr2:144961404-145075430 (+)
AKR/J MGP_AKRJ_G0026538
 protein coding gene Chr2:149197418-149323271 (+)
BALB/cJ MGP_BALBcJ_G0026576
 protein coding gene Chr2:145398999-145518725 (+)
C3H/HeJ MGP_C3HHeJ_G0026319
 protein coding gene Chr2:149653629-149771470 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027021
 protein coding gene Chr2:155511555-155642932 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024398
 protein coding gene Chr2:139047417-139161263 (+)
CAST/EiJ MGP_CASTEiJ_G0025780
 protein coding gene Chr2:150017213-150142153 (+)
CBA/J MGP_CBAJ_G0026299
 protein coding gene Chr2:161197547-161333613 (+)
DBA/2J MGP_DBA2J_G0026433
 protein coding gene Chr2:144239927-144353151 (+)
FVB/NJ MGP_FVBNJ_G0026397
 protein coding gene Chr2:142781474-142891286 (+)
LP/J MGP_LPJ_G0026537
 protein coding gene Chr2:151249195-151365154 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026417
 protein coding gene Chr2:165363446-165482347 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027076
 protein coding gene Chr2:149160125-149277667 (+)
PWK/PhJ MGP_PWKPhJ_G0025515
 protein coding gene Chr2:143931007-144048807 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025316
 protein coding gene Chr2:148143373-148257618 (+)
WSB/EiJ MGP_WSBEiJ_G0025853
 protein coding gene Chr2:150108964-150228598 (+)



Homology
more
  • Human Ortholog
    KIZ, kizuna centrosomal protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIZ, kizuna centrosomal protein
  • Synonyms
    C20orf19, HT013, Kizuna, NCRNA00153, PLK1S1, RP69
  • Links
    NCBI Gene ID: 55857
    neXtProt AC: NX_Q2M2Z5
    UniProt: Q2M2Z5

  • Chr Location
    20p11.23; chr20:21125975-21246622 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KIZ associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Homozygous mutants with truncated C-term transcript were normal size and weight, bred normally with normal litter size, and no obvious defects during fetal or adult development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    837
  • Tissues
    56
  • cDNA Data
    18
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074749 Ensembl Gene Model | MGI Sequence Detail 114234 C57BL/6J ±  kb
transcript ENSMUST00000099278 Ensembl | MGI Sequence Detail 2183 Not Applicable  
polypeptide ENSMUSP00000096884 Ensembl | MGI Sequence Detail 695 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 18
    Primer pair 2
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 34
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory