Gm128 MGI Mouse Gene Detail - MGI:2684974

Symbol

Gm128
Name

predicted gene 128
Synonyms

LOC229588, Ment, Pmis1

Feature Type

protein coding gene
IDs

MGI:2684974
NCBI Gene: 229588
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr3:95144231-95148909 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.74 cM
Mapping Data

1 experiment

SNPs within 2kb

169 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684974	protein coding gene	Chr3:95144230-95148946 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027577	protein coding gene	Chr3:95944458-95949135 (-)
A/J	MGP_AJ_G0027536	protein coding gene	Chr3:92978960-92983692 (-)
AKR/J	MGP_AKRJ_G0027503	protein coding gene	Chr3:95125071-95131629 (-)
BALB/cJ	MGP_BALBcJ_G0027548	protein coding gene	Chr3:92756947-92761591 (-)
C3H/HeJ	MGP_C3HHeJ_G0027281	protein coding gene	Chr3:95411304-95415944 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027996	protein coding gene	Chr3:99510795-99515473 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025336	protein coding gene	Chr3:89340819-89345918 (-)
CAST/EiJ	MGP_CASTEiJ_G0026731	protein coding gene	Chr3:94694668-94701530 (-)
CBA/J	MGP_CBAJ_G0027258	protein coding gene	Chr3:103116688-103124524 (-)
DBA/2J	MGP_DBA2J_G0027397	protein coding gene	Chr3:92271229-92275895 (-)
FVB/NJ	MGP_FVBNJ_G0027368	protein coding gene	Chr3:90346441-90350979 (-)
LP/J	MGP_LPJ_G0027506	protein coding gene	Chr3:97249982-97254707 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027395	protein coding gene	Chr3:109235443-109240120 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028050	protein coding gene	Chr3:94782262-94786985 (-)
PWK/PhJ	MGP_PWKPhJ_G0026459	protein coding gene	Chr3:92149764-92154353 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026280	protein coding gene	Chr3:93075707-93080385 (-)
WSB/EiJ	MGP_WSBEiJ_G0026813	protein coding gene	Chr3:95166122-95171615 (-)

Human Ortholog

C1orf56, chromosome 1 open reading frame 56

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

C1orf56, chromosome 1 open reading frame 56
Synonyms

MENT
Links

HGNC:26045

NCBI Gene ID: 54964

neXtProt AC: NX_Q9BUN1

UniProt: Q9BUN1
Chr Location

1q21.3; chr1:151047751-151051986 (+) GRCh38

MGI Vertebrate Homology

Gm128 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: C1orf56
Gene Tree

Gm128

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Gene trapped

10
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Gm128
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available

A targeted mutation results in slightly decreased fertilization rates for males, although normal litter sizes are produced. Phenotypic analysis of mice homozygous for a gene trap allele indicates no notable phenotype in any parameter tested.

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All GO Annotations

4
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

5
UniProt

3
CCDS

CCDS17608.1

Ensembl

ENSMUSG00000068860 (Evidence)
NCBI Gene

229588

			Length	Strain/Species	Flank
genomic	ENSMUSG00000068860	Ensembl Gene Model \| MGI Sequence Detail	4679	C57BL/6J	± kb
transcript	ENSMUST00000090815	Ensembl \| MGI Sequence Detail	1959	Not Applicable
polypeptide	ENSMUSP00000088324	Ensembl \| MGI Sequence Detail	350	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000060164 protein MENT

(term hierarchy)
InterPro Domains

IPR029292 Methylated in normal thymocytes protein

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All nucleic 6

cDNA 6

Microarray probesets 2

Summaries

All 32

Diseases 1

Gene Ontology 4

Phenotypes 12
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Gm128:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34454	Chr3:95148469-95148493 (-)	428 bp
Tssr34453	Chr3:95148441-95148457 (-)	460 bp
Tssr34452	Chr3:95148355-95148414 (-)	524 bp
Tssr34451	Chr3:95148331-95148336 (-)	575 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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