Ccdc62 MGI Mouse Gene Detail - MGI:2684996 - coiled-coil domain containing 62

Symbol

Ccdc62
Name

coiled-coil domain containing 62
Synonyms

G1-485-3, LOC208908, repro29

Feature Type

protein coding gene
IDs

MGI:2684996
NCBI Gene: 208908
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr5:124068683-124107958 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 63.28 cM
Mapping Data

3 experiments

SNPs within 2kb

946 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684996	protein coding gene	Chr5:124065481-124107958 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030084	protein coding gene	Chr5:127705490-127745306 (+)
A/J	MGP_AJ_G0030049	protein coding gene	Chr5:122399319-122439459 (+)
AKR/J	MGP_AKRJ_G0029985	protein coding gene	Chr5:126338708-126376303 (+)
BALB/cJ	MGP_BALBcJ_G0030060	protein coding gene	Chr5:123728334-123768922 (+)
C3H/HeJ	MGP_C3HHeJ_G0029777	protein coding gene	Chr5:126949525-126988839 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030513	protein coding gene	Chr5:132651166-132690466 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027739	protein coding gene	Chr5:116938416-116977206 (+)
CAST/EiJ	MGP_CASTEiJ_G0029186	protein coding gene	Chr5:126063094-126105686 (+)
CBA/J	MGP_CBAJ_G0029747	protein coding gene	Chr5:137852516-137899970 (+)
DBA/2J	MGP_DBA2J_G0029897	protein coding gene	Chr5:122420583-122458704 (+)
FVB/NJ	MGP_FVBNJ_G0029853	protein coding gene	Chr5:121450223-121488532 (+)
LP/J	MGP_LPJ_G0029986	protein coding gene	Chr5:128244665-128285597 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029884	protein coding gene	Chr5:141465716-141508080 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030554	protein coding gene	Chr5:125945558-125982126 (+)
PWK/PhJ	MGP_PWKPhJ_G0028900	protein coding gene	Chr5:121231826-121270291 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028737	protein coding gene	Chr5:123615601-123655240 (+)
WSB/EiJ	MGP_WSBEiJ_G0029261	protein coding gene	Chr5:126633717-126672549 (+)

Human Ortholog

CCDC62, coiled-coil domain containing 62

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCDC62, coiled-coil domain containing 62
Synonyms

CT109, ERAP75, SPGF67, TSP-NY
Links

HGNC:30723

NCBI Gene ID: 84660

neXtProt AC: NX_Q6P9F0

UniProt: Q6P9F0
Chr Location

12q24.31; chr12:122774526-122827528 (+) GRCh38

MGI Vertebrate Homology

Ccdc62 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCDC62
Gene Tree

Ccdc62

Diseases

1 with human CCDC62 associations

				Human Disease	Mouse Models
				spermatogenic failure 67 IDs spermatogenic failure 67 DOID:0070566 OMIM:619803

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

9
Radiation induced

1
Genomic Mutations

2 involving Ccdc62
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for an ENU-induced mutation or a deletion knockout exhibit male reproductive abnormalities including infertility, low sperm count, abnormal sperm head and tail morphology, very low sperm motility, and low seminal vesicle weight.

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All GO Annotations

16
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

6
cDNA Data

3
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ccdc62

ZFIN ccdc62

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All Sequences

80
RefSeq

50
UniProt

1
CCDS

CCDS51646.1

Ensembl

ENSMUSG00000061882 (Evidence)
NCBI Gene

208908

			Length	Strain/Species	Flank
genomic	208908	NCBI Gene Model \| MGI Sequence Detail	39276	C57BL/6J	± kb
transcript	NM_001134767	RefSeq \| MGI Sequence Detail	3920	C57BL/6
polypeptide	E9PVD1	UniProt \| EBI \| MGI Sequence Detail	701	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000029333 coiled-coil domain-containing protein 62

(term hierarchy)

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All nucleic 4

cDNA 3

Primer pair 1

Microarray probesets 3

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MGI:2140952, MGI:3590181

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 10
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:244081 Li Y, et al., A nonsense mutation in Ccdc62 gene is responsible for spermiogenesis defects and male infertility in repro29/repro29 mice. Biol Reprod. 2017 Mar 01;96(3):587-597

TSS for Ccdc62:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48823	Chr5:124068728-124068737 (+)	50 bp
Tssr48824	Chr5:124068738-124068781 (+)	77 bp
Tssr48825	Chr5:124068786-124068817 (+)	119 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24