Hipk4 MGI Mouse Gene Detail - MGI:2685008 - homeodomain interacting protein kinase 4

Symbol

Hipk4
Name

homeodomain interacting protein kinase 4
Synonyms

LOC233020

Feature Type

protein coding gene
IDs

MGI:2685008
NCBI Gene: 233020
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr7:27222692-27230600 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 15.92 cM
Mapping Data

1 experiment

SNPs within 2kb

298 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685008	protein coding gene	Chr7:27222686-27230605 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031915	protein coding gene	Chr7:26186489-26194397 (+)
A/J	MGP_AJ_G0031894	protein coding gene	Chr7:25551782-25559584 (+)
AKR/J	MGP_AKRJ_G0031824	protein coding gene	Chr7:26233948-26241803 (+)
BALB/cJ	MGP_BALBcJ_G0031899	protein coding gene	Chr7:25766440-25774189 (+)
C3H/HeJ	MGP_C3HHeJ_G0031621	protein coding gene	Chr7:26610274-26618182 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032364	protein coding gene	Chr7:27047882-27055808 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029416	protein coding gene	Chr7:26776818-26785246 (+)
CAST/EiJ	MGP_CASTEiJ_G0030956	protein coding gene	Chr7:19916928-19924823 (+)
CBA/J	MGP_CBAJ_G0031586	protein coding gene	Chr7:28243135-28251043 (+)
DBA/2J	MGP_DBA2J_G0031738	protein coding gene	Chr7:25346881-25354789 (+)
FVB/NJ	MGP_FVBNJ_G0031694	protein coding gene	Chr7:25450188-25458096 (+)
LP/J	MGP_LPJ_G0031818	protein coding gene	Chr7:26515361-26523269 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031729	protein coding gene	Chr7:27812868-27820776 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032395	protein coding gene	Chr7:25771344-25779252 (+)
PWK/PhJ	MGP_PWKPhJ_G0030680	protein coding gene	Chr7:20382875-20390838 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030514	protein coding gene	Chr7:16755723-16763583 (+)
WSB/EiJ	MGP_WSBEiJ_G0031064	protein coding gene	Chr7:26056000-26063906 (+)

Human Ortholog

HIPK4, homeodomain interacting protein kinase 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HIPK4, homeodomain interacting protein kinase 4
Links

HGNC:19007

NCBI Gene ID: 147746

neXtProt AC: NX_Q8NE63

UniProt: Q8NE63
Chr Location

19q13.2; chr19:40379271-40390181 (-) GRCh38

MGI Vertebrate Homology

Hipk4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: HIPK4
Gene Tree

Hipk4

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Phenotype Summary

25 phenotypes from 1 allele in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Gene trapped

3
Targeted

4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a null allele are sterile and exhibit spermatogenic defects characteristic of oligoasthenoteratozoospermia. Sperm are incompetent for oocyte binding and in vitro fertilization and they show head defects associated with dysregulation of the acrosome-acroplaxome complex.

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All GO Annotations

36
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

9
cDNA Data

7
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

4
UniProt

1
CCDS

CCDS21024.2

Ensembl

ENSMUSG00000040424 (Evidence)
NCBI Gene

233020

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040424	Ensembl Gene Model \| MGI Sequence Detail	7909	C57BL/6J	± kb
transcript	ENSMUST00000108353	Ensembl \| MGI Sequence Detail	2409	Not Applicable
polypeptide	ENSMUSP00000103990	Ensembl \| MGI Sequence Detail	616	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008569 homeodomain-interacting protein kinase 4

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050494 Serine/threonine and dual-specificity kinase

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 7

cDNA 7

Microarray probesets 1

Summaries

All 32

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 11
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hipk4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65286	Chr7:27222658-27222667 (+)	-29 bp
Tssr65287	Chr7:27222677-27222694 (+)	-6 bp
Tssr65288	Chr7:27222701-27222710 (+)	14 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24