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Rdh8 Gene Detail
Summary
  • Symbol
    Rdh8
  • Name
    retinol dehydrogenase 8
  • Synonyms
    LOC235033, prRDH
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685028
    NCBI Gene: 235033
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:20729799-20737413 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.64 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    349 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685028
 protein coding gene Chr9:20729790-20739354 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034427
 protein coding gene Chr9:17980026-17991946 (+)
A/J MGP_AJ_G0034405
 protein coding gene Chr9:17687708-17695473 (+)
AKR/J MGP_AKRJ_G0034332
 protein coding gene Chr9:18004574-18012233 (+)
BALB/cJ MGP_BALBcJ_G0034396
 protein coding gene Chr9:17587214-17594873 (+)
C3H/HeJ MGP_C3HHeJ_G0034108
 protein coding gene Chr9:18320140-18327799 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034917
 protein coding gene Chr9:18700134-18707793 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031847
 protein coding gene Chr9:16819379-16827110 (+)
CAST/EiJ MGP_CASTEiJ_G0033431
 protein coding gene Chr9:18142558-18150190 (+)
CBA/J MGP_CBAJ_G0034081
 protein coding gene Chr9:19421342-19432456 (+)
DBA/2J MGP_DBA2J_G0034240
 protein coding gene Chr9:17677283-17684942 (+)
FVB/NJ MGP_FVBNJ_G0034183
 protein coding gene Chr9:17181267-17189186 (+)
LP/J MGP_LPJ_G0034325
 protein coding gene Chr9:18162143-18169828 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034226
 protein coding gene Chr9:21047511-21055656 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034937
 protein coding gene Chr9:17959995-17969069 (+)
PWK/PhJ MGP_PWKPhJ_G0033137
 protein coding gene Chr9:17644576-17652599 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032971
 protein coding gene Chr9:18005486-18014614 (+)
WSB/EiJ MGP_WSBEiJ_G0033546
 protein coding gene Chr9:17690177-17699053 (+)



Homology
more
  • Human Ortholog
    RDH8, retinol dehydrogenase 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RDH8, retinol dehydrogenase 8
  • Synonyms
    PRRDH, SDR28C2
  • Links
    NCBI Gene ID: 50700
    neXtProt AC: NX_Q9NYR8
    UniProt: Q9NYR8

  • Chr Location
    19p13.2; chr19:10013249-10022279 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile but display delayed dark adaptation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    1
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053773 Ensembl Gene Model | MGI Sequence Detail 7615 C57BL/6J ±  kb
    transcript ENSMUST00000066387 Ensembl | MGI Sequence Detail 1405 Not Applicable  
    polypeptide ENSMUSP00000067662 Ensembl | MGI Sequence Detail 317 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • EC
      1.1.1.300
    • InterPro Domains
      IPR011348 17beta-dehydrogenase
      IPR036291 NAD(P)-binding domain superfamily
      IPR020904 Short-chain dehydrogenase/reductase, conserved site
      IPR002347 Short-chain dehydrogenase/reductase SDR
    Molecular
    Reagents
    less

    • Microarray probesets 1
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 2
      Phenotypes 61
    • Earliest
      J:99930 Maeda A, et al., Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem. 2005 May 13;280(19):18822-32
    • Latest
      J:351821 Matsuyama M, et al., Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death. iScience. 2023 Oct 20;26(10):107916
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory