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C2cd4c Gene Detail
Summary
  • Symbol
    C2cd4c
  • Name
    C2 calcium-dependent domain containing 4C
  • Synonyms
    4932409I22Rik, Fam148c, LOC237397
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685084
    NCBI Gene: 237397
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79442688-79449859 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685084
 protein coding gene Chr10:79442688-79449859 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017447
 protein coding gene Chr10:80141258-80150515 (-)
A/J MGP_AJ_G0017425
 protein coding gene Chr10:77356942-77365376 (-)
AKR/J MGP_AKRJ_G0017386
 protein coding gene Chr10:79461087-79468250 (-)
BALB/cJ MGP_BALBcJ_G0017387
 protein coding gene Chr10:77584059-77591910 (-)
C3H/HeJ MGP_C3HHeJ_G0017210
 protein coding gene Chr10:79566105-79573263 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017841
 protein coding gene Chr10:82913615-82922423 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015529
 protein coding gene Chr10:73584260-73591395 (-)
CAST/EiJ MGP_CASTEiJ_G0016777
 protein coding gene Chr10:79740207-79747346 (-)
CBA/J MGP_CBAJ_G0017182
 protein coding gene Chr10:86135657-86145962 (-)
DBA/2J MGP_DBA2J_G0017288
 protein coding gene Chr10:76574753-76583075 (-)
FVB/NJ MGP_FVBNJ_G0017282
 protein coding gene Chr10:75733083-75740240 (-)
LP/J MGP_LPJ_G0017359
 protein coding gene Chr10:80619426-80628289 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017308
 protein coding gene Chr10:88118892-88126048 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017882
 protein coding gene Chr10:79441325-79448486 (-)
PWK/PhJ MGP_PWKPhJ_G0016558
 protein coding gene Chr10:76431285-76438554 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016347
 protein coding gene Chr10:78414957-78422122 (-)
WSB/EiJ MGP_WSBEiJ_G0016837
 protein coding gene Chr10:79469613-79476650 (-)



Homology
more
  • Human Ortholog
    C2CD4C, C2 calcium dependent domain containing 4C
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C2CD4C, C2 calcium dependent domain containing 4C
  • Synonyms
    FAM148C, KIAA1957, NLF3
  • Links
    NCBI Gene ID: 126567
    neXtProt AC: NX_Q8TF44
    UniProt: Q8TF44

  • Chr Location
    19p13.3; chr19:405445-409147 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased body weight but normal glucose homeostasis and pancreas development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    16
  • cDNA Data
    2
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 237397 NCBI Gene Model | MGI Sequence Detail 7172 C57BL/6J ±  kb
    transcript NM_198614 RefSeq | MGI Sequence Detail 6764 C57BL/6  
    polypeptide Q5HZI2 UniProt | EBI | MGI Sequence Detail 419 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      Genomic 2
      cDNA 2
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 1
      Gene Ontology 1
      Phenotypes 10
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:235223 Omori H, et al., Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development. FEBS Lett. 2016 Aug;590(16):2584-93
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory