Cd300lb MGI Mouse Gene Detail - MGI:2685099 - CD300 molecule like family member B

Symbol

Cd300lb
Name

CD300 molecule like family member B
Synonyms

Clm7, CLM-7, LMIR5, LOC217304

Feature Type

protein coding gene
IDs

MGI:2685099
NCBI Gene: 217304
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr11:114813605-114825197 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.55 cM
Mapping Data

1 experiment

SNPs within 2kb

567 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685099	protein coding gene	Chr11:114813605-114825212 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019364	protein coding gene	Chr11:118889468-118904689 (-)
A/J	MGP_AJ_G0019333	protein coding gene	Chr11:113713200-113724870 (-)
AKR/J	MGP_AKRJ_G0019301	protein coding gene	Chr11:117091047-117102604 (-)
BALB/cJ	MGP_BALBcJ_G0019306	protein coding gene	Chr11:114121298-114132842 (-)
C3H/HeJ	MGP_C3HHeJ_G0019115	protein coding gene	Chr11:117427968-117439371 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019757	protein coding gene	Chr11:122451514-122465310 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017381	protein coding gene	Chr11:110792688-110804126 (-)
CAST/EiJ	MGP_CASTEiJ_G0018669	protein coding gene	Chr11:118765068-118779074 (-)
CBA/J	MGP_CBAJ_G0019085	protein coding gene	Chr11:127359509-127371273 (-)
DBA/2J	MGP_DBA2J_G0019197	protein coding gene	Chr11:113150179-113162187 (-)
FVB/NJ	MGP_FVBNJ_G0019188	protein coding gene	Chr11:112631326-112642891 (-)
LP/J	MGP_LPJ_G0019267	protein coding gene	Chr11:119288664-119301233 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019219	protein coding gene	Chr11:126495395-126507040 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019794	protein coding gene	Chr11:117750928-117764100 (-)
PWK/PhJ	MGP_PWKPhJ_G0018434	protein coding gene	Chr11:114386706-114398355 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018226	protein coding gene	Chr11:117559084-117576758 (-)
WSB/EiJ	MGP_WSBEiJ_G0018721	protein coding gene	Chr11:117709294-117721804 (-)

Human Ortholog

CD300LB, CD300 molecule like family member b

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD300LB, CD300 molecule like family member b
Synonyms

CD300b, CLM-7, CLM7, CMRF35-A2, IREM-3, IREM3, TREM-5, TREM5
Links

HGNC:30811

NCBI Gene ID: 124599

neXtProt AC: NX_A8K4G0

UniProt: A8K4G0
Chr Location

17q25.1; chr17:74521174-74531475 (-) GRCh38

MGI Vertebrate Homology

Cd300lb stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CD300LB
Gene Tree

Cd300lb

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
1 images
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Targeted

6
Transgenic

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available

Mice homozygous for a null mutation do not display any gross abnormalities and are protected from ischemia reperfusion induced renal injury.

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

9

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

4
UniProt

4
CCDS

CCDS25614.2, CCDS83924.1

Ensembl

ENSMUSG00000063193 (Evidence)
NCBI Gene

217304

			Length	Strain/Species	Flank
genomic	217304	NCBI Gene Model \| MGI Sequence Detail	11593	C57BL/6J	± kb
transcript	NM_199221	RefSeq \| MGI Sequence Detail	2867	C57BL/6
polypeptide	Q3U497	UniProt \| EBI \| MGI Sequence Detail	209	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005166 CMRF35-like molecule 7

(term hierarchy)
InterPro Domains

IPR050671 CD300 family immune receptors

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain
GlyGen

Q3U497 1 site

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All nucleic 9

cDNA 9

Microarray probesets 2

Summaries

All 35

Gene Ontology 5

Phenotypes 11
Earliest

J:86931 Chung DH, et al., CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. J Immunol. 2003 Dec 15;171(12):6541-8
Latest

J:334747 Avlas S, et al., CD300b regulates intestinal inflammation and promotes repair in colitis. Front Immunol. 2023;14:1050245

TSS for Cd300lb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111686	Chr11:114825177-114825203 (-)	7 bp
Tssr111685	Chr11:114825118-114825125 (-)	75 bp
Tssr111684	Chr11:114825079-114825081 (-)	117 bp
Tssr111683	Chr11:114824594-114824605 (-)	597 bp
Tssr111682	Chr11:114824563-114824578 (-)	626 bp
Tssr111681	Chr11:114821981-114822007 (-)	3,203 bp
Tssr111680	Chr11:114821545-114821556 (-)	3,646 bp
Tssr111679	Chr11:114821525-114821540 (-)	3,664 bp
Tssr111678	Chr11:114821449-114821466 (-)	3,739 bp
Tssr111677	Chr11:114821433-114821448 (-)	3,756 bp
Tssr111676	Chr11:114821226-114821244 (-)	3,962 bp
Tssr111675	Chr11:114821133-114821176 (-)	4,042 bp
Tssr111674	Chr11:114819921-114819952 (-)	5,260 bp
Tssr111673	Chr11:114818919-114818931 (-)	6,272 bp
Tssr111672	Chr11:114815639-114815659 (-)	9,548 bp
Tssr111671	Chr11:114815111-114815126 (-)	10,078 bp
Tssr111670	Chr11:114814795-114814806 (-)	10,396 bp
Tssr111669	Chr11:114814671-114814706 (-)	10,508 bp
Tssr111668	Chr11:114814410-114814426 (-)	10,779 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24