Akap5 MGI Mouse Gene Detail - MGI:2685104 - A kinase anchor protein 5

Symbol

Akap5
Name

A kinase anchor protein 5
Synonyms

3526401B18Rik, AKAP150, LOC238276

Feature Type

protein coding gene
IDs

MGI:2685104
NCBI Gene: 238276
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr12:76371665-76380927 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 33.73 cM
Mapping Data

3 experiments

SNPs within 2kb

306 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685104	protein coding gene	Chr12:76371652-76380927 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019855	protein coding gene	Chr12:76423798-76432984 (+)
A/J	MGP_AJ_G0019813	protein coding gene	Chr12:73528354-73537458 (+)
AKR/J	MGP_AKRJ_G0019788	protein coding gene	Chr12:75750828-75758255 (+)
BALB/cJ	MGP_BALBcJ_G0019792	protein coding gene	Chr12:73999090-74008273 (+)
C3H/HeJ	MGP_C3HHeJ_G0019598	protein coding gene	Chr12:76215593-76224778 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020244	protein coding gene	Chr12:78773258-78782499 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017862	protein coding gene	Chr12:70863876-70873418 (+)
CAST/EiJ	MGP_CASTEiJ_G0019147	protein coding gene	Chr12:70878188-70882622 (-)
CBA/J	MGP_CBAJ_G0019568	protein coding gene	Chr12:81816782-81827425 (+)
DBA/2J	MGP_DBA2J_G0019684	protein coding gene	Chr12:73378802-73387973 (+)
FVB/NJ	MGP_FVBNJ_G0019671	protein coding gene	Chr12:72223533-72232500 (+)
LP/J	MGP_LPJ_G0019756	protein coding gene	Chr12:76405327-76414369 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019710	protein coding gene	Chr12:84848408-84858131 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020280	protein coding gene	Chr12:75228015-75237809 (+)
PWK/PhJ	MGP_PWKPhJ_G0018915	protein coding gene	Chr12:67750916-67760295 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018709	protein coding gene	Chr12:69741024-69750551 (+)
WSB/EiJ	MGP_WSBEiJ_G0019201	protein coding gene	Chr12:75842333-75851570 (+)

Human Ortholog

AKAP5, A-kinase anchoring protein 5

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AKAP5, A-kinase anchoring protein 5
Synonyms

AKAP75, AKAP79, H21
Links

HGNC:375

NCBI Gene ID: 9495

neXtProt AC: NX_P24588

UniProt: P24588
Chr Location

14q23.3; chr14:64465499-64474503 (+) GRCh38

MGI Vertebrate Homology

Akap5 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: AKAP5
Gene Tree

Akap5

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Phenotype Summary

20 phenotypes from 5 alleles in 7 genetic backgrounds
46 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

12
Genomic Mutations

1 involving Akap5
Incidental Mutations

CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced long term potentiation, improved glucose handling and heightened insulin sensitivity.

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All GO Annotations

96
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

18
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GENSAT

GEO

Expression Atlas

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All Sequences

35
RefSeq

4
UniProt

2
CCDS

CCDS49092.1

Ensembl

ENSMUSG00000021057 (Evidence)
NCBI Gene

238276

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021057	Ensembl Gene Model \| MGI Sequence Detail	9263	C57BL/6J	± kb
transcript	ENSMUST00000095610	Ensembl \| MGI Sequence Detail	6687	Not Applicable
polypeptide	ENSMUSP00000093270	Ensembl \| MGI Sequence Detail	752	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003892 A-kinase anchor protein 5

(term hierarchy)
InterPro Domains

IPR001573 A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif

IPR042375 A-kinase anchor protein 5
GlyGen

D3YVF0 1 site, 1 O-linked glycan (1 site)

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All nucleic 18

cDNA 18

Microarray probesets 2

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MGI:1918024, MGI:2145066

Summaries

All 87

Developmental Gene Expression 1

Gene Ontology 18

Phenotypes 46
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:355334 Bai X, et al., Selective activation of AKAP150/TRPV1 in ventrolateral periaqueductal gray GABAergic neurons facilitates conditioned place aversion in male mice. Commun Biol. 2023 Jul 17;6(1):742

TSS for Akap5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113947	Chr12:76371612-76371615 (+)	-51 bp
Tssr113948	Chr12:76371634-76371672 (+)	-12 bp
Tssr113949	Chr12:76371684-76371706 (+)	30 bp
Tssr113950	Chr12:76375703-76375719 (+)	4,046 bp
Tssr113951	Chr12:76375831-76375844 (+)	4,173 bp
Tssr113952	Chr12:76376048-76376057 (+)	4,388 bp
Tssr113953	Chr12:76379179-76379183 (+)	7,516 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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