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Oxgr1 Gene Detail
Summary
  • Symbol
    Oxgr1
  • Name
    oxoglutarate (alpha-ketoglutarate) receptor 1
  • Synonyms
    Cysltr3, Gpr80, Gpr99, LOC239283, P2Y15
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685145
    NCBI Gene: 239283
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:120256997-120279847 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 63.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    813 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685145
 protein coding gene Chr14:120256997-120279847 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021656
 protein coding gene Chr14:117711584-117736417 (-)
A/J MGP_AJ_G0021616
 protein coding gene Chr14:113210842-113236348 (-)
AKR/J MGP_AKRJ_G0021592
 protein coding gene Chr14:116859385-116885946 (-)
BALB/cJ MGP_BALBcJ_G0021622
 protein coding gene Chr14:113750366-113773276 (-)
C3H/HeJ MGP_C3HHeJ_G0021400
 protein coding gene Chr14:116749403-116780908 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022062
 protein coding gene Chr14:122271490-122295296 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019600
 protein coding gene Chr14:109174560-109196653 (-)
CAST/EiJ MGP_CASTEiJ_G0020915
 protein coding gene Chr14:114622179-114648068 (-)
CBA/J MGP_CBAJ_G0021368
 protein coding gene Chr14:126934526-126962490 (-)
DBA/2J MGP_DBA2J_G0021491
 protein coding gene Chr14:113095562-113121796 (-)
FVB/NJ MGP_FVBNJ_G0021469
 protein coding gene Chr14:111402353-111424812 (-)
LP/J MGP_LPJ_G0021559
 protein coding gene Chr14:118716077-118739088 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021496
 protein coding gene Chr14:132004952-132030826 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022085
 protein coding gene Chr14:116386755-116413973 (-)
PWK/PhJ MGP_PWKPhJ_G0020659
 protein coding gene Chr14:110125661-110148620 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020497
 protein coding gene Chr14:112622080-112645691 (-)
WSB/EiJ MGP_WSBEiJ_G0020971
 protein coding gene Chr14:117125183-117149973 (-)



Homology
more
  • Human Ortholog
    OXGR1, oxoglutarate receptor 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OXGR1, oxoglutarate receptor 1
  • Synonyms
    aKGR, CAON2, GPR80, GPR99, P2RY15, P2Y15
  • Links
    NCBI Gene ID: 27199
    neXtProt AC: NX_Q96P68
    UniProt: Q96P68

  • Chr Location
    13q32.1; chr13:96985713-96994730 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human OXGR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced leukotriene E4 ligand (LTE4)-induced ear edema at low and intermediate doses and abnormal acid-base balance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    4
  • cDNA Data
    6
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 239283 NCBI Gene Model | MGI Sequence Detail 22851 C57BL/6J ±  kb
    transcript NM_001001490 RefSeq | MGI Sequence Detail 3732 C57BL/6  
    polypeptide Q6IYF8 UniProt | EBI | MGI Sequence Detail 337 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 6
      Primer pair 1
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 24
    • Earliest
      J:67314 Roix J, et al., Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14. Genetics. 2001 Feb;157(2):803-15
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory