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Jcad Gene Detail
Summary
  • Symbol
    Jcad
  • Name
    junctional cadherin 5 associated
  • Synonyms
    1110056P05Rik, 9430020K01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685174
    NCBI Gene: 240185
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:4634878-4682869 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 3.01 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1060 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685174
 protein coding gene Chr18:4590775-4682869 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024124
 protein coding gene Chr18:1481164-1524387 (+)
A/J MGP_AJ_G0024086
 protein coding gene Chr18:1513304-1559116 (+)
AKR/J MGP_AKRJ_G0024054
 protein coding gene Chr18:1499043-1545805 (+)
BALB/cJ MGP_BALBcJ_G0024086
 protein coding gene Chr18:1499554-1541296 (+)
C3H/HeJ MGP_C3HHeJ_G0023851
 protein coding gene Chr18:1466002-1512197 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024531
 protein coding gene Chr18:1609250-1652441 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021970
 protein coding gene Chr18:1302247-1344672 (+)
CAST/EiJ MGP_CASTEiJ_G0023330
 protein coding gene Chr18:1438983-1483170 (+)
CBA/J MGP_CBAJ_G0023825
 protein coding gene Chr18:1575437-1621721 (+)
DBA/2J MGP_DBA2J_G0023953
 protein coding gene Chr18:1444157-1488397 (+)
FVB/NJ MGP_FVBNJ_G0023919
 protein coding gene Chr18:1415198-1461069 (+)
LP/J MGP_LPJ_G0024037
 protein coding gene Chr18:1572302-1620190 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023947
 protein coding gene Chr18:1606680-1655141 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024576
 protein coding gene Chr18:1444150-1490772 (+)
PWK/PhJ MGP_PWKPhJ_G0023075
 protein coding gene Chr18:1421742-1463893 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022886
 protein coding gene Chr18:1718948-1761615 (+)
WSB/EiJ MGP_WSBEiJ_G0023396
 protein coding gene Chr18:1479617-1525132 (+)



Homology
more
  • Human Ortholog
    JCAD, junctional cadherin 5 associated
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JCAD, junctional cadherin 5 associated
  • Synonyms
    KIAA1462
  • Links
    NCBI Gene ID: 57608
    neXtProt AC: NX_Q9P266
    UniProt: Q9P266

  • Chr Location
    10p11.23; chr10:30012803-30115494 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show decreased body weight and impaired tumor growth and tumor angiogenesis with no apparent defects in physiological vascular development and permeability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    7
  • cDNA Data
    41
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033960 Ensembl Gene Model | MGI Sequence Detail 47992 C57BL/6J ±  kb
    transcript ENSMUST00000037029 Ensembl | MGI Sequence Detail 6782 Not Applicable  
    polypeptide ENSMUSP00000038613 Ensembl | MGI Sequence Detail 1320 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000060126 junctional cadherin 5-associated protein
      (term hierarchy)
    • InterPro Domains
      IPR028221 Junctional cadherin 5-associated protein
    • GlyGen
      Q5DTX6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 41

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1916054, MGI:5897432
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory