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Asxl3 Gene Detail
Summary
  • Symbol
    Asxl3
  • Name
    ASXL transcriptional regulator 3
  • Synonyms
    C230079D11Rik, D430002O22Rik, D930044O18Rik, LOC381127
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685175
    NCBI Gene: 211961
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:22477303-22663072 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 11.96 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4263 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685175
 protein coding gene Chr18:22477195-22663284 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024190
 protein coding gene Chr18:20031894-20217775 (+)
A/J MGP_AJ_G0024155
 protein coding gene Chr18:19474390-19653771 (+)
AKR/J MGP_AKRJ_G0024124
 protein coding gene Chr18:20081890-20273354 (+)
BALB/cJ MGP_BALBcJ_G0024155
 protein coding gene Chr18:19543100-19730192 (+)
C3H/HeJ MGP_C3HHeJ_G0023923
 protein coding gene Chr18:20004729-20192488 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024597
 protein coding gene Chr18:20936070-21126074 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022039
 protein coding gene Chr18:19405828-19583037 (+)
CAST/EiJ MGP_CASTEiJ_G0023396
 protein coding gene Chr18:19800447-19993718 (+)
CBA/J MGP_CBAJ_G0023891
 protein coding gene Chr18:21472978-21662925 (+)
DBA/2J MGP_DBA2J_G0024023
 protein coding gene Chr18:19174603-19354639 (+)
FVB/NJ MGP_FVBNJ_G0023989
 protein coding gene Chr18:18940765-19119304 (+)
LP/J MGP_LPJ_G0024104
 protein coding gene Chr18:20180223-20371460 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024017
 protein coding gene Chr18:22432258-22634089 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024645
 protein coding gene Chr18:19840262-20033249 (+)
PWK/PhJ MGP_PWKPhJ_G0023141
 protein coding gene Chr18:19298327-19486084 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022950
 protein coding gene Chr18:19993056-20187764 (+)
WSB/EiJ MGP_WSBEiJ_G0023461
 protein coding gene Chr18:19749024-19939742 (+)



Homology
more
  • Human Ortholog
    ASXL3, ASXL transcriptional regulator 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASXL3, ASXL transcriptional regulator 3
  • Synonyms
    BRPS, KIAA1713
  • Links
    NCBI Gene ID: 80816
    neXtProt AC: NX_Q9C0F0
    UniProt: Q9C0F0

  • Chr Location
    18q12.1; chr18:33578219-33751195 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ASXL3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from multigenic genotypes
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    4
  • cDNA Data
    23
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045215 Ensembl Gene Model | MGI Sequence Detail 185770 C57BL/6J ±  kb
transcript ENSMUST00000239326 Ensembl | MGI Sequence Detail 11353 Not Applicable  
polypeptide ENSMUSP00000159205 Ensembl | MGI Sequence Detail 2260 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 23
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2444723, MGI:2685791, MGI:3026936
References
more
  • Summaries
    All 42
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:350469 Alderman PJ, et al., Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala. Neuron. 2024 Feb 21;112(4):574-592.e10
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory