Megf10 MGI Mouse Gene Detail - MGI:2685177 - multiple EGF-like-domains 10

Symbol

Megf10
Name

multiple EGF-like-domains 10
Synonyms

3000002B06Rik, LOC240312

Feature Type

protein coding gene
IDs

MGI:2685177
NCBI Gene: 70417
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr18:57266162-57430539 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 31.50 cM
Mapping Data

2 experiments

SNPs within 2kb

4591 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685177	protein coding gene	Chr18:57266162-57430539 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024447	protein coding gene	Chr18:56552235-56717660 (+)
A/J	MGP_AJ_G0024413	protein coding gene	Chr18:54311007-54471188 (+)
AKR/J	MGP_AKRJ_G0024383	protein coding gene	Chr18:55803125-55968073 (+)
BALB/cJ	MGP_BALBcJ_G0024413	protein coding gene	Chr18:54485593-54645497 (+)
C3H/HeJ	MGP_C3HHeJ_G0024180	protein coding gene	Chr18:56010306-56173631 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024859	protein coding gene	Chr18:58334438-58517535 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022291	protein coding gene	Chr18:53913554-54071563 (+)
CAST/EiJ	MGP_CASTEiJ_G0023654	protein coding gene	Chr18:56042233-56206986 (+)
CBA/J	MGP_CBAJ_G0024150	protein coding gene	Chr18:60177858-60373336 (+)
DBA/2J	MGP_DBA2J_G0024280	protein coding gene	Chr18:54003213-54172085 (+)
FVB/NJ	MGP_FVBNJ_G0024247	protein coding gene	Chr18:53397427-53559616 (+)
LP/J	MGP_LPJ_G0024365	protein coding gene	Chr18:56507214-56682444 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024277	protein coding gene	Chr18:61818683-61990673 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024906	protein coding gene	Chr18:55918189-56081438 (+)
PWK/PhJ	MGP_PWKPhJ_G0023398	protein coding gene	Chr18:54028725-54188898 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023204	protein coding gene	Chr18:56007306-56160910 (+)
WSB/EiJ	MGP_WSBEiJ_G0023717	protein coding gene	Chr18:55842142-56006336 (+)

Human Ortholog

MEGF10, multiple EGF like domains 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MEGF10, multiple EGF like domains 10
Synonyms

CMYO10A, CMYO10B, CMYP10A, CMYP10B, EMARDD, SR-F3
Links

HGNC:29634

NCBI Gene ID: 84466

neXtProt AC: NX_Q96KG7

UniProt: Q96KG7
Chr Location

5q23.2; chr5:127229300-127465737 (+) GRCh38

MGI Vertebrate Homology

Megf10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MEGF10
Gene Tree

Megf10

Diseases

2 with human MEGF10 associations

				Human Disease	Mouse Models
				congenital myopathy 10B IDs congenital myopathy 10B DOID:0081345 OMIM:620249
				early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome IDs early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome DOID:0111333 OMIM:614399 ORDO:439212

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Spontaneous

1
Targeted

5
Genomic Mutations

1 involving Megf10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

69 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a targeted allele exhibit abnormal spacing of starburst amacrine cells and horizontal cells. Homozygotes for another targeted allele exhibit impaired phagocytosis of apoptotic cells by astrocytes. Mice heterozygous for this same allele exhibit mild disorganization of starburts amacrine cells.

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All GO Annotations

35
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

771
Tissues

35
cDNA Data

24
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase megf10

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All Sequences

33
RefSeq

2
UniProt

2
CCDS

CCDS29264.1

Ensembl

ENSMUSG00000024593 (Evidence)
NCBI Gene

70417

			Length	Strain/Species	Flank
genomic	70417	NCBI Gene Model \| MGI Sequence Detail	164378	C57BL/6J	± kb
transcript	NM_001001979	RefSeq \| MGI Sequence Detail	7514	C57BL/6
polypeptide	Q6DIB5	UniProt \| EBI \| MGI Sequence Detail	1147	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010314 multiple epidermal growth factor-like domains protein 10

(term hierarchy)
InterPro Domains

IPR013032 EGF-like, conserved site

IPR000742 EGF-like domain

IPR013111 EGF-like domain, extracellular

IPR011489 EMI domain

IPR002049 Laminin-type EGF domain

IPR052108 Multiple EGF-like domains/Integrin beta-like
GlyGen

Q6DIB5 6 sites, 4 N-linked glycans (4 sites)

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All nucleic 30

cDNA 24

Primer pair 4

Other 2

Microarray probesets 2

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MGI:1917667

Summaries

All 50

Developmental Gene Expression 9

Gene Ontology 11

Phenotypes 17
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:353797 Kozlowski C, et al., Retinal neurons establish mosaic patterning by excluding homotypic somata from their dendritic territories. Cell Rep. 2024 Aug 27;43(8):114615

TSS for Megf10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151176	Chr18:57266041-57266075 (+)	-104 bp
Tssr151177	Chr18:57266080-57266101 (+)	-71 bp
Tssr151178	Chr18:57266124-57266135 (+)	-32 bp
Tssr151179	Chr18:57266137-57266151 (+)	-18 bp
Tssr151180	Chr18:57266438-57266441 (+)	278 bp
Tssr151181	Chr18:57266445-57266494 (+)	308 bp
Tssr151182	Chr18:57266519-57266534 (+)	365 bp
Tssr151183	Chr18:57266538-57266576 (+)	395 bp
Tssr151184	Chr18:57275690-57275700 (+)	9,533 bp
Tssr151185	Chr18:57275742-57275766 (+)	9,592 bp
Tssr151186	Chr18:57275777-57275782 (+)	9,618 bp
Tssr151187	Chr18:57275786-57275807 (+)	9,635 bp
Tssr151188	Chr18:57275810-57275827 (+)	9,657 bp
Tssr151189	Chr18:57275828-57275837 (+)	9,671 bp
Tssr151190	Chr18:57275854-57275868 (+)	9,699 bp
Tssr151191	Chr18:57275895-57275900 (+)	9,736 bp
Tssr151192	Chr18:57275909-57275930 (+)	9,758 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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