Nxf3 MGI Mouse Gene Detail - MGI:2685230 - nuclear RNA export factor 3

Symbol

Nxf3
Name

nuclear RNA export factor 3
Synonyms

LOC245610

Feature Type

protein coding gene
IDs

MGI:2685230
NCBI Gene: 245610
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

ChrX:134972848-134986004 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 57.38 cM
Mapping Data

2 experiments

SNPs within 2kb

362 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685230	protein coding gene	ChrX:134972272-135040382 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0036093	protein coding gene	ChrX:133429807-133447929 (-)
A/J	MGP_AJ_G0036074	protein coding gene	ChrX:132831827-132844648 (-)
AKR/J	MGP_AKRJ_G0036000	protein coding gene	ChrX:137096406-137110567 (-)
BALB/cJ	MGP_BALBcJ_G0036062	protein coding gene	ChrX:131220149-131233550 (-)
C3H/HeJ	MGP_C3HHeJ_G0035772	protein coding gene	ChrX:133420362-133433557 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036585	protein coding gene	ChrX:137264561-137277748 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033415	protein coding gene	ChrX:124829621-124841977 (-)
CAST/EiJ	MGP_CASTEiJ_G0035061	protein coding gene	ChrX:114345371-114361441 (-)
CBA/J	MGP_CBAJ_G0035748	protein coding gene	ChrX:141485480-141502029 (-)
DBA/2J	MGP_DBA2J_G0035903	protein coding gene	ChrX:132175630-132189175 (-)
FVB/NJ	MGP_FVBNJ_G0035839	protein coding gene	ChrX:131343572-131357223 (-)
LP/J	MGP_LPJ_G0035997	protein coding gene	ChrX:134358834-134372622 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035873	protein coding gene	ChrX:148874102-148888288 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036622	protein coding gene	ChrX:132782747-132797928 (-)
PWK/PhJ	MGP_PWKPhJ_G0034752	protein coding gene	ChrX:111258289-111271558 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034583	protein coding gene	ChrX:114995799-115008798 (-)
WSB/EiJ	MGP_WSBEiJ_G0035194	protein coding gene	ChrX:131120185-131133356 (-)

Human Ortholog

NXF3, nuclear RNA export factor 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NXF3, nuclear RNA export factor 3
Links

HGNC:8073

NCBI Gene ID: 56000

neXtProt AC: NX_Q9H4D5

UniProt: Q9H4D5
Chr Location

Xq22.1; chrX:103075810-103093143 (-) GRCh38

MGI Vertebrate Homology

Nxf3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NXF3
Gene Tree

Nxf3

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 2 alleles in 3 genetic backgrounds
10 phenotypes from multigenic genotypes
5 phenotype references

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Genomic Mutations

2 involving Nxf3
Find Mice (IMSR)

8 strains or lines available

Mice homozygous for a knock-out allele exhibit normal fertility and male reproductive system morphology.

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All GO Annotations

13
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

9
cDNA Data

6
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

48
RefSeq

19
UniProt

2
CCDS

CCDS41132.1

Ensembl

ENSMUSG00000057000 (Evidence)
NCBI Gene

245610

			Length	Strain/Species	Flank
genomic	ENSMUSG00000057000	Ensembl Gene Model \| MGI Sequence Detail	13157	C57BL/6J	± kb
transcript	ENSMUST00000080929	Ensembl \| MGI Sequence Detail	2978	Not Applicable
polypeptide	ENSMUSP00000079730	Ensembl \| MGI Sequence Detail	553	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR032710 NTF2-like domain superfamily

IPR030217 Nuclear RNA export factor

IPR015245 Nuclear RNA export factor Tap, RNA-binding domain

IPR002075 Nuclear transport factor 2 domain

IPR018222 Nuclear transport factor 2, eukaryote

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR005637 TAP C-terminal (TAP-C) domain

IPR009060 UBA-like superfamily

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All nucleic 7

cDNA 6

Primer pair 1

Microarray probesets 3

Summaries

All 22

Developmental Gene Expression 2

Diseases 1

Gene Ontology 3

Phenotypes 5
Earliest

J:97549 Sasaki M, et al., Molecular cloning and functional characterization of mouse Nxf family gene products. Genomics. 2005 May;85(5):641-53
Latest

J:210663 Zhou J, et al., Respiratory failure, cleft palate and epilepsy in the mouse model of human Xq22.1 deletion syndrome. Hum Mol Genet. 2014 Jul 15;23(14):3823-9

TSS for Nxf3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164180	ChrX:134986135-134986152 (-)	-140 bp
Tssr164179	ChrX:134985955-134985999 (-)	27 bp
Tssr164178	ChrX:134985945-134985953 (-)	55 bp
Tssr164177	ChrX:134985917-134985922 (-)	84 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24