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Vwde Gene Detail
Summary
  • Symbol
    Vwde
  • Name
    von Willebrand factor D and EGF domains
  • Synonyms
    LOC232585
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685313
    NCBI Gene: 232585
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr6:13156439-13224964 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 5.64 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2593 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685313
 protein coding gene Chr6:13156298-13224964 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030458
 protein coding gene Chr6:10233948-10310865 (-)
A/J MGP_AJ_G0030431
 protein coding gene Chr6:9842519-9909463 (-)
AKR/J MGP_AKRJ_G0030358
 protein coding gene Chr6:10186036-10254612 (-)
BALB/cJ MGP_BALBcJ_G0030440
 protein coding gene Chr6:9836864-9920780 (-)
C3H/HeJ MGP_C3HHeJ_G0030154
 protein coding gene Chr6:10103267-10176172 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030895
 protein coding gene Chr6:10673076-10747727 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028106
 protein coding gene Chr6:9087549-9157809 (-)
CAST/EiJ MGP_CASTEiJ_G0029556
 protein coding gene Chr6:9969033-10040543 (-)
CBA/J MGP_CBAJ_G0030132
 protein coding gene Chr6:10869878-10983722 (-)
DBA/2J MGP_DBA2J_G0030276
 protein coding gene Chr6:9769526-9841895 (-)
FVB/NJ MGP_FVBNJ_G0030230
 protein coding gene Chr6:9675272-9744026 (-)
LP/J MGP_LPJ_G0030363
 protein coding gene Chr6:10191395-10278208 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030266
 protein coding gene Chr6:11618162-11710932 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030925
 protein coding gene Chr6:10065520-10134217 (-)
PWK/PhJ MGP_PWKPhJ_G0029270
 protein coding gene Chr6:9524636-9594488 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029106
 protein coding gene Chr6:9985140-10055633 (-)
WSB/EiJ MGP_WSBEiJ_G0029632
 protein coding gene Chr6:9996864-10077157 (-)



Homology
more
  • Human Ortholog
    VWDE, von Willebrand factor D and EGF domains
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VWDE, von Willebrand factor D and EGF domains
  • Links
    NCBI Gene ID: 221806
    neXtProt AC: NX_Q8N2E2
    UniProt: Q8N2E2

  • Chr Location
    7p21.3; chr7:12330885-12403941 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit slight tooth discoloration, cracked molars, and reduced molar enamel mineral density.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    24
  • cDNA Data
    4
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 232585 NCBI Gene Model | MGI Sequence Detail 68526 C57BL/6J ±  kb
    transcript NM_001368871 RefSeq | MGI Sequence Detail 5485 C57BL/6  
    polypeptide Q6DFV8 UniProt | EBI | MGI Sequence Detail 926 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000030387 von Willebrand factor D and EGF domain-containing protein
      (term hierarchy)
    • InterPro Domains
      IPR050969 Developmental Signaling Modulators
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR001846 von Willebrand factor, type D domain
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 4
      Primer pair 3
      Other 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 17
      Developmental Gene Expression 1
      Gene Ontology 1
      Phenotypes 4
    • Earliest
      J:324628 Iwata K, et al., von Willebrand factor D and EGF domains regulate ameloblast differentiation and enamel formation. J Cell Physiol. 2022 Mar;237(3):1964-1979
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory