Usp49 MGI Mouse Gene Detail - MGI:2685391 - ubiquitin specific peptidase 49

Symbol

Usp49
Name

ubiquitin specific peptidase 49
Synonyms

C330046L10Rik

Feature Type

protein coding gene
IDs

MGI:2685391
NCBI Gene: 224836
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr17:47941615-47997663 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 23.72 cM
Mapping Data

1 experiment

SNPs within 2kb

1125 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685391	protein coding gene	Chr17:47941615-47997664 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023851	protein coding gene	Chr17:48832932-48896551 (+)
A/J	MGP_AJ_G0023811	protein coding gene	Chr17:47583080-47638749 (+)
AKR/J	MGP_AKRJ_G0023780	protein coding gene	Chr17:47994939-48056895 (+)
BALB/cJ	MGP_BALBcJ_G0023813	protein coding gene	Chr17:47493164-47551775 (+)
C3H/HeJ	MGP_C3HHeJ_G0023576	protein coding gene	Chr17:48724960-48784385 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024257	protein coding gene	Chr17:50876386-50940583 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021706	protein coding gene	Chr17:44335536-44396239 (+)
CAST/EiJ	MGP_CASTEiJ_G0023058	protein coding gene	Chr17:48841230-48895763 (+)
CBA/J	MGP_CBAJ_G0023553	protein coding gene	Chr17:52722732-52786690 (+)
DBA/2J	MGP_DBA2J_G0023681	protein coding gene	Chr17:46338462-46394712 (+)
FVB/NJ	MGP_FVBNJ_G0023647	protein coding gene	Chr17:45996740-46052388 (+)
LP/J	MGP_LPJ_G0023761	protein coding gene	Chr17:49488561-49550901 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023675	protein coding gene	Chr17:52199423-52262139 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024302	protein coding gene	Chr17:48352286-48410607 (+)
PWK/PhJ	MGP_PWKPhJ_G0022803	protein coding gene	Chr17:45711436-45769028 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022618	protein coding gene	Chr17:45242253-45296742 (+)
WSB/EiJ	MGP_WSBEiJ_G0023123	protein coding gene	Chr17:48930750-48990281 (+)

Human Ortholog

USP49, ubiquitin specific peptidase 49

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

USP49, ubiquitin specific peptidase 49
Links

HGNC:20078

NCBI Gene ID: 25862

neXtProt AC: NX_Q70CQ1

UniProt: Q70CQ1
Chr Location

6p21.1; chr6:41789896-41895375 (-) GRCh38

MGI Vertebrate Homology

Usp49 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: USP49
Gene Tree

Usp49

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout reduces susceptibility to DNA virus infection.

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All GO Annotations

19
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

46
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase usp49

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All Sequences

38
RefSeq

2
UniProt

4
CCDS

CCDS28852.1

Ensembl

ENSMUSG00000090115 (Evidence)
NCBI Gene

224836

			Length	Strain/Species	Flank
genomic	ENSMUSG00000090115	Ensembl Gene Model \| MGI Sequence Detail	56049	C57BL/6J	± kb
transcript	ENSMUST00000024779	Ensembl \| MGI Sequence Detail	8252	Not Applicable
polypeptide	ENSMUSP00000024779	Ensembl \| MGI Sequence Detail	685	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017188 ubiquitin carboxyl-terminal hydrolase 49

(term hierarchy)
EC

3.4.19.12
InterPro Domains

IPR038765 Papain-like cysteine peptidase superfamily

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase

IPR050185 Ubiquitin carboxyl-terminal hydrolase

IPR018200 Ubiquitin specific protease, conserved site

IPR028889 Ubiquitin specific protease domain

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001607 Zinc finger, UBP-type

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All nucleic 46

cDNA 46

Microarray probesets 2

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 7
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Usp49:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144989	Chr17:47940711-47940724 (+)	-897 bp
Tssr144990	Chr17:47940815-47940893 (+)	-761 bp
Tssr144991	Chr17:47941445-47941448 (+)	-168 bp
Tssr144992	Chr17:47966732-47966734 (+)	25,118 bp
Tssr144993	Chr17:47968934-47968939 (+)	27,322 bp
Tssr144994	Chr17:47973913-47973916 (+)	32,300 bp
Tssr144995	Chr17:47979684-47979717 (+)	38,086 bp
Tssr144996	Chr17:47983593-47983605 (+)	41,984 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24