Zfp217 MGI Mouse Gene Detail - MGI:2685408

Symbol

Zfp217
Name

zinc finger protein 217
Synonyms

4933431C08Rik

Feature Type

protein coding gene
IDs

MGI:2685408
NCBI Gene: 228913
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr2:169950563-169990023 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 89.91 cM
Mapping Data

4 experiments

SNPs within 2kb

841 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685408	protein coding gene	Chr2:169950563-169993598 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026933	protein coding gene	Chr2:176123808-176164685 (-)
A/J	MGP_AJ_G0026900	protein coding gene	Chr2:168771684-168814669 (-)
AKR/J	MGP_AKRJ_G0026871	protein coding gene	Chr2:173833936-173873342 (-)
BALB/cJ	MGP_BALBcJ_G0026909	protein coding gene	Chr2:169148297-169188082 (-)
C3H/HeJ	MGP_C3HHeJ_G0026651	protein coding gene	Chr2:174207640-174247040 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027356	protein coding gene	Chr2:181198878-181238302 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024726	protein coding gene	Chr2:162077020-162116221 (-)
CAST/EiJ	MGP_CASTEiJ_G0026109	protein coding gene	Chr2:174769555-174814125 (-)
CBA/J	MGP_CBAJ_G0026628	protein coding gene	Chr2:187948199-187987752 (-)
DBA/2J	MGP_DBA2J_G0026766	protein coding gene	Chr2:167868321-167908480 (-)
FVB/NJ	MGP_FVBNJ_G0026732	protein coding gene	Chr2:166467376-166506749 (-)
LP/J	MGP_LPJ_G0026867	protein coding gene	Chr2:176095051-176134509 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026751	protein coding gene	Chr2:191077066-191120324 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027413	protein coding gene	Chr2:173773663-173814005 (-)
PWK/PhJ	MGP_PWKPhJ_G0025846	protein coding gene	Chr2:167584164-167624857 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025646	protein coding gene	Chr2:172784181-172827031 (-)
WSB/EiJ	MGP_WSBEiJ_G0026182	protein coding gene	Chr2:174713128-174752532 (-)

Human Ortholog

ZNF217, zinc finger protein 217

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF217, zinc finger protein 217
Synonyms

ZABC1
Links

HGNC:13009

NCBI Gene ID: 7764

neXtProt AC: NX_O75362

UniProt: O75362
Chr Location

20q13.2; chr20:53567071-53609907 (-) GRCh38

MGI Vertebrate Homology

Zfp217 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZNF217
Gene Tree

Zfp217

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

65
Endonuclease-mediated

4
Gene trapped

61
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

90 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Knock-out mice show prenatal lethality. Heterozygotes are resistant to high-fat diet-induced obesity, have smaller adipocytes, improved glucose tolerance and insulin sensitivity, and increased energy expenditure on this diet.

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All GO Annotations

15
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

19
cDNA Data

30
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase znf217

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All Sequences

65
RefSeq

24
UniProt

2
CCDS

CCDS17120.1

Ensembl

ENSMUSG00000052056 (Evidence)
NCBI Gene

228913

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052056	Ensembl Gene Model \| MGI Sequence Detail	39461	C57BL/6J	± kb
transcript	ENSMUST00000109155	Ensembl \| MGI Sequence Detail	5670	Not Applicable
polypeptide	ENSMUSP00000104783	Ensembl \| MGI Sequence Detail	1041	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR051967 Krueppel C2H2-type Zinc-Finger Domain-Containing Protein

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 32

cDNA 30

Primer pair 1

Other 1

Microarray probesets 3

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MGI:2139421, MGI:2152733

Summaries

All 37

Developmental Gene Expression 4

Gene Ontology 3

Phenotypes 8
Earliest

J:83702 Buttitta L, et al., Microarray analysis of somitogenesis reveals novel targets of different WNT signaling pathways in the somitic mesoderm. Dev Biol. 2003 Jun 1;258(1):91-104
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Zfp217:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr27910	Chr2:169984593-169984598 (-)	5,427 bp
Tssr27909	Chr2:169983527-169983531 (-)	6,494 bp
Tssr27908	Chr2:169976492-169976503 (-)	13,525 bp
Tssr27907	Chr2:169976447-169976476 (-)	13,561 bp
Tssr27906	Chr2:169975462-169975485 (-)	14,549 bp
Tssr27905	Chr2:169973957-169973971 (-)	16,059 bp
Tssr27904	Chr2:169973076-169973104 (-)	16,933 bp
Tssr27903	Chr2:169963997-169964004 (-)	26,022 bp
Tssr27902	Chr2:169950828-169950837 (-)	39,190 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24