Nuggc MGI Mouse Gene Detail - MGI:2685446 - nuclear GTPase, germinal center associated

Symbol

Nuggc
Name

nuclear GTPase, germinal center associated
Synonyms

Gm600, LOC239151, SLIP-GC

Feature Type

protein coding gene
IDs

MGI:2685446
NCBI Gene: 100503545
Alliance

gene page

Sequence Map

Chr14:65835995-65885980 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 34.34 cM
Mapping Data

1 experiment

SNPs within 2kb

1621 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685446	protein coding gene	Chr14:65830901-65885980 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021482	protein coding gene	Chr14:60212235-60268323 (+)
A/J	MGP_AJ_G0021441	protein coding gene	Chr14:58817808-58868492 (+)
AKR/J	MGP_AKRJ_G0021417	protein coding gene	Chr14:60858849-60911007 (+)
BALB/cJ	MGP_BALBcJ_G0021447	protein coding gene	Chr14:58753605-58804971 (+)
C3H/HeJ	MGP_C3HHeJ_G0021224	protein coding gene	Chr14:60497882-60551266 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021886	protein coding gene	Chr14:62989430-63046348 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019426	protein coding gene	Chr14:56748395-56799478 (+)
CAST/EiJ	MGP_CASTEiJ_G0020741	protein coding gene	Chr14:56984319-57037878 (+)
CBA/J	MGP_CBAJ_G0021191	protein coding gene	Chr14:64893111-64952000 (+)
DBA/2J	MGP_DBA2J_G0021314	protein coding gene	Chr14:58466047-58516988 (+)
FVB/NJ	MGP_FVBNJ_G0021293	protein coding gene	Chr14:57866027-57916596 (+)
LP/J	MGP_LPJ_G0021389	protein coding gene	Chr14:61246910-61304902 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021322	protein coding gene	Chr14:63995133-64053048 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021909	protein coding gene	Chr14:60038812-60093488 (+)
PWK/PhJ	MGP_PWKPhJ_G0020485	protein coding gene	Chr14:55177199-55229829 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020318	protein coding gene	Chr14:56003504-56066643 (+)
WSB/EiJ	MGP_WSBEiJ_G0020794	protein coding gene	Chr14:60347686-60401273 (+)

Human Ortholog

NUGGC, nuclear GTPase, germinal center associated

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUGGC, nuclear GTPase, germinal center associated
Synonyms

C8orf80, HMFN0672, SLIP-GC, SLIPGC
Links

HGNC:33550

NCBI Gene ID: 389643

neXtProt AC: NX_Q68CJ6

UniProt: Q68CJ6
Chr Location

8p21.1; chr8:28021964-28083936 (-) GRCh38

MGI Vertebrate Homology

Nuggc stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: NUGGC
Gene Tree

Nuggc

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

3
Targeted

5
Genomic Mutations

1 involving Nuggc
Incidental Mutations

APF
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased somatic mutation frequency immunoglobulin and non-immunoglobulin loci in B cells.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

37
RefSeq

11
UniProt

2
CCDS

CCDS56966.1

Ensembl

ENSMUSG00000061356 (Evidence)
NCBI Gene

100503545

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061356	Ensembl Gene Model \| MGI Sequence Detail	49986	C57BL/6J	± kb
transcript	ENSMUST00000079469	Ensembl \| MGI Sequence Detail	2567	Not Applicable
polypeptide	ENSMUSP00000078434	Ensembl \| MGI Sequence Detail	812	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030625 nuclear GTPase SLIP-GC

(term hierarchy)
EC

3.6.1.-
InterPro Domains

IPR045063 Dynamin, N-terminal

IPR053082 Nuclear GTPase SLIP-GC

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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Microarray probesets 1

Summaries

All 24

Gene Ontology 5

Phenotypes 11
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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