Slc9c1 MGI Mouse Gene Detail - MGI:2685456 - solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1

Symbol

Slc9c1
Name

solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
Synonyms

LOC208169, Slc9a10, spermNHE

Feature Type

protein coding gene
IDs

MGI:2685456
NCBI Gene: 208169
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr16:45355672-45427364 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 29.53 cM
Mapping Data

1 experiment

SNPs within 2kb

1970 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685456	protein coding gene	Chr16:45355629-45427364 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022853	protein coding gene	Chr16:44317986-44388093 (+)
A/J	MGP_AJ_G0022818	protein coding gene	Chr16:42339943-42405711 (+)
AKR/J	MGP_AKRJ_G0022790	protein coding gene	Chr16:43729700-43797637 (+)
BALB/cJ	MGP_BALBcJ_G0022819	protein coding gene	Chr16:42360950-42426997 (+)
C3H/HeJ	MGP_C3HHeJ_G0022583	protein coding gene	Chr16:43889598-43962083 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023266	protein coding gene	Chr16:45328104-45409330 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020780	protein coding gene	Chr16:42701073-42761171 (+)
CAST/EiJ	MGP_CASTEiJ_G0022108	protein coding gene	Chr16:44075484-44152156 (+)
CBA/J	MGP_CBAJ_G0022554	protein coding gene	Chr16:47232649-47316538 (+)
DBA/2J	MGP_DBA2J_G0022686	protein coding gene	Chr16:42077771-42143860 (+)
FVB/NJ	MGP_FVBNJ_G0022662	protein coding gene	Chr16:41990687-42055970 (+)
LP/J	MGP_LPJ_G0022754	protein coding gene	Chr16:44056327-44125424 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022680	protein coding gene	Chr16:46661479-46733120 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023281	protein coding gene	Chr16:43742807-43811142 (+)
PWK/PhJ	MGP_PWKPhJ_G0021848	protein coding gene	Chr16:42445044-42511355 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021679	protein coding gene	Chr16:43670571-43749053 (+)
WSB/EiJ	MGP_WSBEiJ_G0022153	protein coding gene	Chr16:43835544-43907696 (+)

Human Ortholog

SLC9C1, solute carrier family 9 member C1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC9C1, solute carrier family 9 member C1
Synonyms

NHE, NHE-10, SLC9A10, sperm-NHE
Links

HGNC:31401

NCBI Gene ID: 285335

neXtProt AC: NX_Q4G0N8

UniProt: Q4G0N8
Chr Location

3q13.2; chr3:112140898-112294227 (-) GRCh38

MGI Vertebrate Homology

Slc9c1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SLC9C1
Gene Tree

Slc9c1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

67 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display male infertility and asthenozoospermia.

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

43
RefSeq

8
UniProt

3
CCDS

CCDS28198.2

Ensembl

ENSMUSG00000033210 (Evidence)
NCBI Gene

208169

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033210	Ensembl Gene Model \| MGI Sequence Detail	71693	C57BL/6J	± kb
transcript	ENSMUST00000159945	Ensembl \| MGI Sequence Detail	3836	Not Applicable
polypeptide	ENSMUSP00000124969	Ensembl \| MGI Sequence Detail	1175	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015211 sodium/hydrogen exchanger 10

(term hierarchy)
InterPro Domains

IPR006153 Cation/H+ exchanger

IPR018422 Cation/H+ exchanger, CPA1 family

IPR000595 Cyclic nucleotide-binding domain

IPR018490 Cyclic nucleotide-binding domain superfamily

IPR005821 Ion transport domain

IPR014710 RmlC-like jelly roll fold

IPR027359 Voltage-dependent channel domain superfamily

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All nucleic 3

cDNA 3

Microarray probesets 1

Summaries

All 26

Gene Ontology 6

Phenotypes 7
Earliest

J:85118 Oduru S, et al., Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. BMC Genomics. 2003 Jun 3;4(1):22
Latest

J:328456 Hernandez-Garduno S, et al., Hyperpolarization induces cytosolic alkalization of mouse sperm flagellum probably through sperm Na+/H+ exchanger. Reproduction. 2022 Oct 1;164(4):125-134

TSS for Slc9c1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138627	Chr16:45355655-45355664 (+)	-12 bp
Tssr138628	Chr16:45355666-45355680 (+)	1 bp
Tssr138629	Chr16:45355688-45355699 (+)	22 bp
Tssr138630	Chr16:45355703-45355717 (+)	38 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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