Arhgef40 MGI Mouse Gene Detail - MGI:2685515 - Rho guanine nucleotide exchange factor 40

Symbol

Arhgef40
Name

Rho guanine nucleotide exchange factor 40
Synonyms

E130112L23Rik

Feature Type

protein coding gene
IDs

MGI:2685515
NCBI Gene: 268739
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:52222176-52243708 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 26.75 cM
Mapping Data

1 experiment

SNPs within 2kb

489 from dbSNP Build 142
Strain Annotations

29

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685515	protein coding gene	Chr14:52222158-52243708 (+)
129S1/SvImJ	ENSMUSGG00200054942	protein coding gene	Chr14:41024996-41042253 (+)
129S1/SvImJ	ENSMUSG00200016427	protein coding gene	Chr14:41023205-41025709 (+)
A/J	ENSMUSG00195024372	protein coding gene	Chr14:41252405-41254909 (+)
A/J	ENSMUSGG00195054956	protein coding gene	Chr14:41254196-41271461 (+)
AKR/J	ENSMUSG00220032014	protein coding gene	Chr14:40608299-40610803 (+)
AKR/J	ENSMUSGG00220054428	protein coding gene	Chr14:40610090-40627348 (+)
BALB/cJ	ENSMUSG00180040383	protein coding gene	Chr14:40881378-40883882 (+)
BALB/cJ	ENSMUSGG00180055211	protein coding gene	Chr14:40883776-40885462 (+)
C3H/HeJ	ENSMUSG00175044979	protein coding gene	Chr14:42535556-42538060 (+)
C3H/HeJ	ENSMUSGG00175054637	protein coding gene	Chr14:42537347-42554599 (+)
C57BL/6NJ	ENSMUSG00215025124	protein coding gene	Chr14:41232798-41235301 (+)
C57BL/6NJ	ENSMUSGG00215055696	protein coding gene	Chr14:41234590-41252196 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019231	protein coding gene	Chr14:43998832-44020421 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210034502	protein coding gene	Chr14:41235022-41237526 (+)
CBA/J	ENSMUSGG00210054576	protein coding gene	Chr14:41237420-41239108 (+)
DBA/2J	ENSMUSGG00185057429	protein coding gene	Chr14:46149389-46166656 (+)
DBA/2J	ENSMUSG00185050973	protein coding gene	Chr14:46147598-46150103 (+)
FVB/NJ	ENSMUSG00205030421	protein coding gene	Chr14:40481862-40484366 (+)
FVB/NJ	ENSMUSGG00205054223	protein coding gene	Chr14:40484260-40501605 (+)
JF1/MsJ	ENSUMUGG00000058152	protein coding gene	Chr14:58060127-58077441 (+)
LP/J	ENSMUSGG00230055320	protein coding gene	Chr14:58399621-58416876 (+)
LP/J	ENSMUSG00230051947	protein coding gene	Chr14:58397830-58400334 (+)
NOD/ShiLtJ	ENSMUSG00190033821	protein coding gene	Chr14:40916344-40918848 (+)
NOD/ShiLtJ	ENSMUSGG00190054577	protein coding gene	Chr14:40918135-40935402 (+)
NZO/HlLtJ	ENSMUSGG00225055588	protein coding gene	Chr14:48698322-48700008 (+)
NZO/HlLtJ	ENSMUSG00225048560	protein coding gene	Chr14:48695924-48698428 (+)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010042657	protein coding gene	Chr14:44143539-44163716 (+)
WSB/EiJ	ENSIUOGG00005053817	protein coding gene	Chr14:40639176-40656449 (+)

Human Ortholog

ARHGEF40, Rho guanine nucleotide exchange factor 40

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGEF40, Rho guanine nucleotide exchange factor 40
Synonyms

SOLO
Links

HGNC:25516

NCBI Gene ID: 55701

UniProt: Q8TER5
Chr Location

14q11.2; chr14:21061264-21090248 (+) GRCh38

MGI Vertebrate Homology

Arhgef40 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARHGEF40
Gene Tree

Arhgef40

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

3
Genomic Mutations

1 involving Arhgef40
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

55 strains or lines available

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

600
Tissues

2
cDNA Data

11
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN arhgef40

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All Sequences

127
RefSeq

28
UniProt

11
CCDS

CCDS49488.1, CCDS49489.1, CCDS59616.1

Ensembl

ENSMUSG00000004562 (Evidence)
NCBI Gene

268739

			Length	Strain/Species	Flank
genomic	ENSMUSG00000004562	Ensembl Gene Model \| MGI Sequence Detail	21533	C57BL/6J	± kb
transcript	ENSMUST00000182760	Ensembl \| MGI Sequence Detail	5130	Not Applicable
polypeptide	ENSMUSP00000138125	Ensembl \| MGI Sequence Detail	1526	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000015405 Rho guanine nucleotide exchange factor 40

(term hierarchy)
InterPro Domains

IPR035899 Dbl homology (DH) domain superfamily

IPR000219 Dbl homology domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR060651 Rho guanine nucleotide exchange factor 40-like, C-terminal domain

IPR060650 Rho guanine nucleotide exchange factor 40-like, N-terminal domain

IPR052231 Rho guanine nucleotide exchange factor 40-related

IPR055251 SOS1/NGEF-like, PH domain
GlyGen

Q3UPH7 2 sites, 1 O-linked glycan (1 site)

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 6

Summaries

All 33

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 7
Earliest

J:92574 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Apr 30;11(2):127-35
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arhgef40:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125437	Chr14:52221945-52221970 (+)	-218 bp
Tssr125438	Chr14:52221983-52221995 (+)	-187 bp
Tssr125439	Chr14:52222153-52222178 (+)	-10 bp
Tssr125440	Chr14:52222283-52222313 (+)	122 bp
Tssr125441	Chr14:52222314-52222365 (+)	164 bp
Tssr125442	Chr14:52226494-52226521 (+)	4,332 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24