Slc9a5 MGI Mouse Gene Detail - MGI:2685542 - solute carrier family 9 (sodium/hydrogen exchanger), member 5

Symbol

Slc9a5
Name

solute carrier family 9 (sodium/hydrogen exchanger), member 5
Synonyms

LOC277973

Feature Type

protein coding gene
IDs

MGI:2685542
NCBI Gene: 277973
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr8:106075475-106096513 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 53.04 cM
Mapping Data

1 experiment

SNPs within 2kb

497 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685542	protein coding gene	Chr8:106074782-106096513 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034042	protein coding gene	Chr8:107622143-107645296 (+)
A/J	MGP_AJ_G0034023	protein coding gene	Chr8:103326699-103348422 (+)
AKR/J	MGP_AKRJ_G0033949	protein coding gene	Chr8:106310955-106336433 (+)
BALB/cJ	MGP_BALBcJ_G0034016	protein coding gene	Chr8:103502169-103524745 (+)
C3H/HeJ	MGP_C3HHeJ_G0033728	protein coding gene	Chr8:107062114-107085017 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034536	protein coding gene	Chr8:111567234-111589152 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031478	protein coding gene	Chr8:96475879-96497335 (+)
CAST/EiJ	MGP_CASTEiJ_G0033054	protein coding gene	Chr8:106558742-106580457 (+)
CBA/J	MGP_CBAJ_G0033701	protein coding gene	Chr8:115175588-115203735 (+)
DBA/2J	MGP_DBA2J_G0033856	protein coding gene	Chr8:102672051-102693601 (+)
FVB/NJ	MGP_FVBNJ_G0033802	protein coding gene	Chr8:101595627-101618270 (+)
LP/J	MGP_LPJ_G0033947	protein coding gene	Chr8:107827764-107852368 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033845	protein coding gene	Chr8:118379392-118402352 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034554	protein coding gene	Chr8:106288137-106311135 (+)
PWK/PhJ	MGP_PWKPhJ_G0032755	protein coding gene	Chr8:102059408-102081504 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032596	protein coding gene	Chr8:104961904-104983476 (+)
WSB/EiJ	MGP_WSBEiJ_G0033170	protein coding gene	Chr8:106940412-106963062 (+)

Human Ortholog

SLC9A5, solute carrier family 9 member A5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC9A5, solute carrier family 9 member A5
Synonyms

NHE5
Links

HGNC:11078

NCBI Gene ID: 6553

neXtProt AC: NX_Q14940

UniProt: Q14940
Chr Location

16q22.1; chr16:67237683-67272191 (+) GRCh38

MGI Vertebrate Homology

Slc9a5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC9A5
Gene Tree

Slc9a5

Diseases

1 with human SLC9A5 associations

				Human Disease	Mouse Models
				end stage renal disease IDs end stage renal disease DOID:783

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit enhanced learning and memory and synapse morphology.

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All GO Annotations

32
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

9
cDNA Data

32
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc9a5

ZFIN slc9a5

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All Sequences

57
RefSeq

28
UniProt

1
CCDS

CCDS40457.1

Ensembl

ENSMUSG00000014786 (Evidence)
NCBI Gene

277973

			Length	Strain/Species	Flank
genomic	ENSMUSG00000014786	Ensembl Gene Model \| MGI Sequence Detail	21039	C57BL/6J	± kb
transcript	ENSMUST00000073149	Ensembl \| MGI Sequence Detail	3499	Not Applicable
polypeptide	ENSMUSP00000072893	Ensembl \| MGI Sequence Detail	898	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015217 sodium/hydrogen exchanger 5

(term hierarchy)
InterPro Domains

IPR006153 Cation/H+ exchanger

IPR018422 Cation/H+ exchanger, CPA1 family

IPR004709 Na+/H+ exchanger

IPR018410 Na+/H+ exchanger, isoforms 3/5

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All nucleic 34

cDNA 32

Primer pair 2

Microarray probesets 2

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 9
Earliest

J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc9a5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79137	Chr8:106074724-106074731 (+)	-747 bp
Tssr79138	Chr8:106074795-106074822 (+)	-666 bp
Tssr79139	Chr8:106075927-106076001 (+)	489 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24