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Wfdc8 Gene Detail
Summary
  • Symbol
    Wfdc8
  • Name
    WAP four-disulfide core domain 8
  • Synonyms
    LOC277343
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685552
    NCBI Gene: 277343
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164438378-164455545 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    698 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685552
 protein coding gene Chr2:164438378-164455546 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026861
 protein coding gene Chr2:170063917-170091995 (-)
A/J MGP_AJ_G0026828
 protein coding gene Chr2:163129402-163148107 (-)
AKR/J MGP_AKRJ_G0026797
 protein coding gene Chr2:167971281-167989305 (-)
BALB/cJ MGP_BALBcJ_G0026836
 protein coding gene Chr2:163490989-163508065 (-)
C3H/HeJ MGP_C3HHeJ_G0026577
 protein coding gene Chr2:168334147-168357117 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027283
 protein coding gene Chr2:175003602-175022467 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024653
 protein coding gene Chr2:156533410-156556727 (-)
CAST/EiJ MGP_CASTEiJ_G0026037
 protein coding gene Chr2:168754016-168769528 (-)
CBA/J MGP_CBAJ_G0026555
 protein coding gene Chr2:181332662-181360733 (-)
DBA/2J MGP_DBA2J_G0026693
 protein coding gene Chr2:162297577-162314720 (-)
FVB/NJ MGP_FVBNJ_G0026659
 protein coding gene Chr2:160717891-160734493 (-)
LP/J MGP_LPJ_G0026795
 protein coding gene Chr2:170146080-170165316 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026679
 protein coding gene Chr2:184912830-184929700 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027341
 protein coding gene Chr2:167882087-167899076 (-)
PWK/PhJ MGP_PWKPhJ_G0025774
 protein coding gene Chr2:161897565-161914543 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025575
 protein coding gene Chr2:166780956-166800862 (-)
WSB/EiJ MGP_WSBEiJ_G0026109
 protein coding gene Chr2:168754877-168780953 (-)



Homology
more
  • Human Ortholog
    WFDC8, WAP four-disulfide core domain 8
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WFDC8, WAP four-disulfide core domain 8
  • Synonyms
    C20orf170, dJ461P17.1, HEL-S-292, WAP8
  • Links
    NCBI Gene ID: 90199
    neXtProt AC: NX_Q8IUA0
    UniProt: Q8IUA0

  • Chr Location
    20q13.12; chr20:45551152-45579326 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    13
  • cDNA Data
    2
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 277343 NCBI Gene Model | MGI Sequence Detail 17168 C57BL/6J ±  kb
transcript NM_001276432 RefSeq | MGI Sequence Detail 3474 C57BL/6  
polypeptide Q4KUS1 UniProt | EBI | MGI Sequence Detail 273 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000031266 WAP four-disulfide core domain protein 8
    (term hierarchy)
  • InterPro Domains
    IPR036645 Elafin-like superfamily
    IPR002223 Pancreatic trypsin inhibitor Kunitz domain
    IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
    IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
    IPR042931 WAP four-disulfide core domain protein 8/12/15B-like
    IPR008197 WAP-type 'four-disulfide core' domain
  • GlyGen
    Q4KUS1 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 3
    cDNA 2
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 19
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 2
  • Earliest
    J:84763 Sivashanmugam P, et al., Characterization of mouse Eppin and a gene cluster of similar protease inhibitors on mouse chromosome 2. Gene. 2003 Jul 17;312:125-34
  • Latest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory