Hsf5 MGI Mouse Gene Detail - MGI:2685585 - heat shock transcription factor family member 5

Symbol

Hsf5
Name

heat shock transcription factor family member 5
Synonyms

LOC327992

Feature Type

protein coding gene
IDs

MGI:2685585
NCBI Gene: 327992
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:87507990-87550368 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 52.16 cM
Mapping Data

1 experiment

SNPs within 2kb

74 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685585	protein coding gene	Chr11:87507225-87550715 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018908	protein coding gene	Chr11:89244858-89291030 (+)
A/J	MGP_AJ_G0018875	protein coding gene	Chr11:85800492-85843478 (+)
AKR/J	MGP_AKRJ_G0018845	protein coding gene	Chr11:88369793-88412080 (+)
BALB/cJ	MGP_BALBcJ_G0018848	protein coding gene	Chr11:86198025-86241383 (+)
C3H/HeJ	MGP_C3HHeJ_G0018662	protein coding gene	Chr11:88408869-88451104 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019300	protein coding gene	Chr11:91949849-91992066 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016933	protein coding gene	Chr11:82830213-82873165 (+)
CAST/EiJ	MGP_CASTEiJ_G0018217	protein coding gene	Chr11:89099111-89143785 (+)
CBA/J	MGP_CBAJ_G0018633	protein coding gene	Chr11:95807457-95855001 (+)
DBA/2J	MGP_DBA2J_G0018741	protein coding gene	Chr11:85354785-85397400 (+)
FVB/NJ	MGP_FVBNJ_G0018730	protein coding gene	Chr11:84862295-84905469 (+)
LP/J	MGP_LPJ_G0018811	protein coding gene	Chr11:89735341-89777657 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018757	protein coding gene	Chr11:95862813-95910776 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019340	protein coding gene	Chr11:88608555-88652571 (+)
PWK/PhJ	MGP_PWKPhJ_G0017987	protein coding gene	Chr11:86202543-86245826 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017780	protein coding gene	Chr11:88172637-88217305 (+)
WSB/EiJ	MGP_WSBEiJ_G0018268	protein coding gene	Chr11:88489674-88534878 (+)

Human Ortholog

HSF5, heat shock transcription factor 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSF5, heat shock transcription factor 5
Synonyms

HSF 5, HSTF 5
Links

HGNC:26862

NCBI Gene ID: 124535

neXtProt AC: NX_Q4G112

UniProt: Q4G112
Chr Location

17q22; chr17:58420167-58488408 (-) GRCh38

MGI Vertebrate Homology

Hsf5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HSF5
Gene Tree

Hsf5

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

1
Genomic Mutations

2 involving Hsf5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null males are infertile, with small testes, arrest of spermatogenesis during meiosis with sex chromosome defects and azoospermia.

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

804
Tissues

98
cDNA Data

7
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hsf5

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All Sequences

32
RefSeq

4
UniProt

1
CCDS

CCDS36269.1

Ensembl

ENSMUSG00000070345 (Evidence)
NCBI Gene

327992

			Length	Strain/Species	Flank
genomic	ENSMUSG00000070345	Ensembl Gene Model \| MGI Sequence Detail	42379	C57BL/6J	± kb
transcript	ENSMUST00000093956	Ensembl \| MGI Sequence Detail	4158	Not Applicable
polypeptide	ENSMUSP00000091488	Ensembl \| MGI Sequence Detail	624	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008794 heat shock factor protein 5

(term hierarchy)
InterPro Domains

IPR000232 Heat shock factor (HSF)-type, DNA-binding

IPR027725 Heat shock transcription factor family

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 9

cDNA 7

Primer pair 2

Microarray probesets 2

Summaries

All 35

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 12
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:347775 Yoshimura S, et al., Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions. Nat Commun. 2024 Apr 29;15(1):3330

TSS for Hsf5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103947	Chr11:87507977-87507990 (+)	-6 bp
Tssr103948	Chr11:87508002-87508026 (+)	24 bp
Tssr103949	Chr11:87508037-87508048 (+)	53 bp
Tssr103950	Chr11:87508052-87508073 (+)	73 bp
Tssr103951	Chr11:87508079-87508084 (+)	92 bp
Tssr103952	Chr11:87548447-87548452 (+)	40,460 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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