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Heca Gene Detail
Summary
  • Symbol
    Heca
  • Name
    hdc homolog, cell cycle regulator
  • Synonyms
    LOC380629
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685715
    NCBI Gene: 380629
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:17774788-17823785 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 7.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1146 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685715
 protein coding gene Chr10:17744360-17823815 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017033
 protein coding gene Chr10:15557540-15603305 (-)
A/J MGP_AJ_G0017011
 protein coding gene Chr10:14950997-14996983 (-)
AKR/J MGP_AKRJ_G0016975
 protein coding gene Chr10:15188014-15239437 (-)
BALB/cJ MGP_BALBcJ_G0016969
 protein coding gene Chr10:15029466-15074583 (-)
C3H/HeJ MGP_C3HHeJ_G0016794
 protein coding gene Chr10:15519024-15575284 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017431
 protein coding gene Chr10:15939174-15988494 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015136
 protein coding gene Chr10:13874250-13921910 (-)
CAST/EiJ MGP_CASTEiJ_G0016376
 protein coding gene Chr10:15320210-15369984 (-)
CBA/J MGP_CBAJ_G0016766
 protein coding gene Chr10:16648888-16704753 (-)
DBA/2J MGP_DBA2J_G0016874
 protein coding gene Chr10:14848019-14896030 (-)
FVB/NJ MGP_FVBNJ_G0016869
 protein coding gene Chr10:14620114-14667401 (-)
LP/J MGP_LPJ_G0016949
 protein coding gene Chr10:15371513-15422317 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016899
 protein coding gene Chr10:17008326-17058631 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017469
 protein coding gene Chr10:15173775-15224835 (-)
PWK/PhJ MGP_PWKPhJ_G0016161
 protein coding gene Chr10:14671680-14719292 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015944
 protein coding gene Chr10:15322705-15372757 (-)
WSB/EiJ MGP_WSBEiJ_G0016438
 protein coding gene Chr10:15241202-15289075 (-)



Homology
more
  • Human Ortholog
    HECA, hdc homolog, cell cycle regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HECA, hdc homolog, cell cycle regulator
  • Synonyms
    dJ225E12.1, HDC, HDCL, HHDC
  • Links
    NCBI Gene ID: 51696
    neXtProt AC: NX_Q9UBI9
    UniProt: Q9UBI9

  • Chr Location
    6q24.1; chr6:139135080-139180802 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 380629 NCBI Gene Model | MGI Sequence Detail 48998 C57BL/6J ±  kb
    transcript NM_001033432 RefSeq | MGI Sequence Detail 5061 C57BL/6  
    polypeptide NP_001028604 RefSeq | MGI Sequence Detail 544 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR031947 Headcase, middle domain
      IPR026066 Headcase protein
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 4
    References
    more
    • Summaries
      All 26
      Gene Ontology 1
      Phenotypes 8
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory