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Garem1 Gene Detail
Summary
  • Symbol
    Garem1
  • Name
    GRB2 associated regulator of MAPK1 subtype 1
  • Synonyms
    Fam59a, Garem, LOC381126
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685790
    NCBI Gene: 381126
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:21260258-21433195 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 11.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4657 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685790
 protein coding gene Chr18:21257916-21433196 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0024152
 protein coding gene Chr18:18259071-18428339 (-)
AKR/J MGP_AKRJ_G0024121
 protein coding gene Chr18:18819131-18988988 (-)
BALB/cJ MGP_BALBcJ_G0024152
 protein coding gene Chr18:18315181-18481497 (-)
C3H/HeJ MGP_C3HHeJ_G0023920
 protein coding gene Chr18:18762392-18929798 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024594
 protein coding gene Chr18:19647090-19816301 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022036
 protein coding gene Chr18:17379202-17544574 (-)
CAST/EiJ MGP_CASTEiJ_G0023393
 protein coding gene Chr18:18545022-18719355 (-)
CBA/J MGP_CBAJ_G0023888
 protein coding gene Chr18:20164442-20342646 (-)
DBA/2J MGP_DBA2J_G0024020
 protein coding gene Chr18:17963385-18129908 (-)
FVB/NJ MGP_FVBNJ_G0023986
 protein coding gene Chr18:17742460-17907804 (-)
LP/J MGP_LPJ_G0024101
 protein coding gene Chr18:18915280-19089975 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024014
 protein coding gene Chr18:21040879-21219117 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024642
 protein coding gene Chr18:18592684-18761748 (-)
PWK/PhJ MGP_PWKPhJ_G0023138
 protein coding gene Chr18:18054860-18239263 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022947
 protein coding gene Chr18:18771211-18950307 (-)
WSB/EiJ MGP_WSBEiJ_G0023458
 protein coding gene Chr18:18509042-18678709 (-)



Homology
more
  • Human Ortholog
    GAREM1, GRB2 associated regulator of MAPK1 subtype 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GAREM1, GRB2 associated regulator of MAPK1 subtype 1
  • Synonyms
    C18orf11, FAM59A, GAREM, Gm944
  • Links
    NCBI Gene ID: 64762
    neXtProt AC: NX_Q9H706
    UniProt: Q9H706

  • Chr Location
    18q12.1; chr18:32124877-32470882 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice are slightly lighter than wild-type around 10 weeks of age; however, they are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    819
  • Tissues
    14
  • cDNA Data
    28
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042680 Ensembl Gene Model | MGI Sequence Detail 172938 C57BL/6J ±  kb
    transcript ENSMUST00000049260 Ensembl | MGI Sequence Detail 4923 Not Applicable  
    polypeptide ENSMUSP00000048914 Ensembl | MGI Sequence Detail 876 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 28

      Microarray probesets 4
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory