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Cplx4 Gene Detail
Summary
  • Symbol
    Cplx4
  • Name
    complexin 4
  • Synonyms
    A930004D23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685803
    NCBI Gene: 225644
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:66088793-66103249 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 39.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    525 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685803
 protein coding gene Chr18:66088793-66103308 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024514
 protein coding gene Chr18:66146018-66160530 (-)
A/J MGP_AJ_G0024481
 protein coding gene Chr18:63255318-63270428 (-)
AKR/J MGP_AKRJ_G0024451
 protein coding gene Chr18:65040923-65060455 (-)
BALB/cJ MGP_BALBcJ_G0024480
 protein coding gene Chr18:63396634-63413810 (-)
C3H/HeJ MGP_C3HHeJ_G0024248
 protein coding gene Chr18:65258818-65273935 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024927
 protein coding gene Chr18:67899797-67917475 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022358
 protein coding gene Chr18:62697110-62711753 (-)
CAST/EiJ MGP_CASTEiJ_G0023721
 protein coding gene Chr18:65255212-65273692 (-)
CBA/J MGP_CBAJ_G0024218
 protein coding gene Chr18:70144981-70161671 (-)
DBA/2J MGP_DBA2J_G0024348
 protein coding gene Chr18:62923597-62938080 (-)
FVB/NJ MGP_FVBNJ_G0024314
 protein coding gene Chr18:62301094-62316168 (-)
LP/J MGP_LPJ_G0024432
 protein coding gene Chr18:65991516-66006578 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024343
 protein coding gene Chr18:71534441-71549808 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024974
 protein coding gene Chr18:65257735-65272275 (-)
PWK/PhJ MGP_PWKPhJ_G0023464
 protein coding gene Chr18:63176056-63191024 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023269
 protein coding gene Chr18:65414811-65430236 (-)
WSB/EiJ MGP_WSBEiJ_G0023785
 protein coding gene Chr18:65120769-65138577 (-)



Homology
more
  • Human Ortholog
    CPLX4, complexin 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPLX4, complexin 4
  • Synonyms
    CPX-IV, CPXIV
  • Links
    NCBI Gene ID: 339302
    neXtProt AC: NX_Q7Z7G2
    UniProt: Q7Z7G2

  • Chr Location
    18q21.32; chr18:59275156-59318649 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation are viable and fertile displaying only slight abnormalities in eye electrophysiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    8
  • cDNA Data
    14
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 225644 NCBI Gene Model | MGI Sequence Detail 14457 C57BL/6J ±  kb
    transcript NM_145493 RefSeq | MGI Sequence Detail 1767 Not Specified  
    polypeptide Q80WM3 UniProt | EBI | MGI Sequence Detail 160 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 2
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:93300 Blackshaw S, et al., Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
    • Latest
      J:346242 Lux UT, et al., Light-dependent regulation of neurotransmitter release from rod photoreceptor ribbon synapses involves an interplay of Complexin 4 and Transducin with the SNARE complex. Front Mol Neurosci. 2024;17:1308466
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory