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Top6bl Gene Detail
Summary
  • Symbol
    Top6bl
  • Name
    TOP6B like initiator of meiotic double strand breaks
  • Synonyms
    Gm960, Top6bl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685806
    NCBI Gene: 381196
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr19:4675762-4748696 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2072 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685806
 protein coding gene Chr19:4675758-4748753 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024669
 protein coding gene Chr19:1513009-1587632 (-)
A/J MGP_AJ_G0024635
 protein coding gene Chr19:1436058-1515419 (-)
AKR/J MGP_AKRJ_G0024608
 protein coding gene Chr19:1477900-1552109 (-)
BALB/cJ MGP_BALBcJ_G0024635
 protein coding gene Chr19:1431355-1505801 (-)
C3H/HeJ MGP_C3HHeJ_G0024403
 protein coding gene Chr19:1484788-1559716 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0022512
 protein coding gene Chr19:1371168-1445415 (-)
CAST/EiJ MGP_CASTEiJ_G0023875
 protein coding gene Chr19:1495026-1575487 (-)
CBA/J MGP_CBAJ_G0024374
 protein coding gene Chr19:1632426-1712366 (-)
DBA/2J MGP_DBA2J_G0024502
 protein coding gene Chr19:1400074-1473106 (-)
FVB/NJ MGP_FVBNJ_G0024469
 protein coding gene Chr19:1426222-1501633 (-)
LP/J MGP_LPJ_G0024588
 protein coding gene Chr19:1521655-1595518 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024499
 protein coding gene Chr19:1546427-1619673 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025130
 protein coding gene Chr19:1476590-1553155 (-)
PWK/PhJ MGP_PWKPhJ_G0023621
 protein coding gene Chr19:1458404-1526579 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023426
 protein coding gene Chr19:1468631-1544380 (-)
WSB/EiJ MGP_WSBEiJ_G0023937
 protein coding gene Chr19:1472223-1547092 (-)



Homology
more
  • Human Ortholog
    TOP6BL, TOP6B like initiator of meiotic double strand breaks
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOP6BL, TOP6B like initiator of meiotic double strand breaks
  • Synonyms
    C11orf80, HYDM4, TOPOVIBL
  • Links
    NCBI Gene ID: 79703
    neXtProt AC: NX_Q8N6T0
    UniProt: Q8N6T0

  • Chr Location
    11q13.2; chr11:66744451-66843516 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TOP6BL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired double-strand break formation that imapires female and male meiosis and results in no spermatids and reduced primary and primordial follicle numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    22
  • cDNA Data
    4
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071691 Ensembl Gene Model | MGI Sequence Detail 72935 C57BL/6J ±  kb
    transcript ENSMUST00000177696 Ensembl | MGI Sequence Detail 2262 Not Applicable  
    polypeptide ENSMUSP00000136515 Ensembl | MGI Sequence Detail 753 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 4
      Primer pair 3

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:7525395
    References
    more
    • Summaries
      All 20
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 5
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:331787 Nore A, et al., TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks. Nat Commun. 2022 Nov 17;13(1):7048
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory