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Hpse2 Gene Detail
Summary
  • Symbol
    Hpse2
  • Name
    heparanase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685814
    NCBI Gene: 545291
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:42774978-43376794 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 36.57 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    13462 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685814
 protein coding gene Chr19:42774978-43376913 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025150
 protein coding gene Chr19:42146986-42767972 (-)
A/J MGP_AJ_G0025127
 protein coding gene Chr19:40117595-40740321 (-)
AKR/J MGP_AKRJ_G0025095
 protein coding gene Chr19:41415901-42029094 (-)
BALB/cJ MGP_BALBcJ_G0025121
 protein coding gene Chr19:40187578-40787068 (-)
C3H/HeJ MGP_C3HHeJ_G0024881
 protein coding gene Chr19:41575724-42213376 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025564
 protein coding gene Chr19:43219356-43847104 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022978
 protein coding gene Chr19:39468036-40036682 (-)
CAST/EiJ MGP_CASTEiJ_G0024346
 protein coding gene Chr19:41275992-41901436 (-)
CBA/J MGP_CBAJ_G0024861
 protein coding gene Chr19:45326572-46018675 (-)
DBA/2J MGP_DBA2J_G0024993
 protein coding gene Chr19:39958006-40574612 (-)
FVB/NJ MGP_FVBNJ_G0024954
 protein coding gene Chr19:39738266-40328715 (-)
LP/J MGP_LPJ_G0025079
 protein coding gene Chr19:42126271-42748175 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024985
 protein coding gene Chr19:44908789-45572487 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025622
 protein coding gene Chr19:41491218-42115103 (-)
PWK/PhJ MGP_PWKPhJ_G0024095
 protein coding gene Chr19:39862154-40468992 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023899
 protein coding gene Chr19:40230967-40835342 (-)
WSB/EiJ MGP_WSBEiJ_G0024416
 protein coding gene Chr19:41625233-42256654 (-)



Homology
more
  • Human Ortholog
    HPSE2, heparanase 2 (inactive)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HPSE2, heparanase 2 (inactive)
  • Synonyms
    HPA2, HPR2, UFS, UFS1
  • Links
    NCBI Gene ID: 60495
    neXtProt AC: NX_Q8WWQ2
    UniProt: Q8WWQ2

  • Chr Location
    10q24.2; chr10:98457077-99315951 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hpse2 mouse models; 1 with human HPSE2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele exhibit growth retardation, a distended urinary bladder, abnormal voiding behavior, proteinuria, renal dysfunction and malnutrition, reduced cell proliferation, urinary bladder fibrosis, and lethality within one month of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    8
  • cDNA Data
    11
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074852 Ensembl Gene Model | MGI Sequence Detail 601817 C57BL/6J ±  kb
    transcript ENSMUST00000099428 Ensembl | MGI Sequence Detail 4231 Not Applicable  
    polypeptide ENSMUSP00000097026 Ensembl | MGI Sequence Detail 592 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory