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Cfap58 Gene Detail
Summary
  • Symbol
    Cfap58
  • Name
    cilia and flagella associated protein 58
  • Synonyms
    Ccdc147, LOC381229
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685815
    NCBI Gene: 381229
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:47926151-48023818 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 40.60 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3433 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685815
 protein coding gene Chr19:47926114-48023826 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025237
 protein coding gene Chr19:47805581-47917524 (+)
A/J MGP_AJ_G0025213
 protein coding gene Chr19:45400521-45502234 (+)
AKR/J MGP_AKRJ_G0025182
 protein coding gene Chr19:46870144-46974356 (+)
BALB/cJ MGP_BALBcJ_G0025208
 protein coding gene Chr19:45456399-45553310 (+)
C3H/HeJ MGP_C3HHeJ_G0024968
 protein coding gene Chr19:47045101-47146856 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025651
 protein coding gene Chr19:48924596-49030300 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023064
 protein coding gene Chr19:44598920-44696771 (+)
CAST/EiJ MGP_CASTEiJ_G0024433
 protein coding gene Chr19:46865673-46996921 (+)
CBA/J MGP_CBAJ_G0024948
 protein coding gene Chr19:51398785-51502504 (+)
DBA/2J MGP_DBA2J_G0025080
 protein coding gene Chr19:45218297-45314901 (+)
FVB/NJ MGP_FVBNJ_G0025041
 protein coding gene Chr19:44988032-45086743 (+)
LP/J MGP_LPJ_G0025166
 protein coding gene Chr19:47685921-47796530 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025072
 protein coding gene Chr19:50624613-50733510 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025709
 protein coding gene Chr19:46992966-47101179 (+)
PWK/PhJ MGP_PWKPhJ_G0024182
 protein coding gene Chr19:45172246-45294829 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023985
 protein coding gene Chr19:45645057-45770126 (+)
WSB/EiJ MGP_WSBEiJ_G0024503
 protein coding gene Chr19:47146086-47249443 (+)



Homology
more
  • Human Ortholog
    CFAP58, cilia and flagella associated protein 58
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CFAP58, cilia and flagella associated protein 58
  • Synonyms
    bA127L20.4, bA127L20.5, bA554P13.1, C10orf80, CCDC147, SPGF49
  • Links
    NCBI Gene ID: 159686
    neXtProt AC: NX_Q5T655
    UniProt: Q5T655

  • Chr Location
    10q25.1; chr10:104338520-104455102 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cfap58 mouse models; 1 with human CFAP58 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects spermatogenesis and leads to male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 381229 NCBI Gene Model | MGI Sequence Detail 97668 C57BL/6J ±  kb
    transcript NM_001163267 RefSeq | MGI Sequence Detail 3345 C57BL/6  
    polypeptide B2RW38 UniProt | EBI | MGI Sequence Detail 873 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000032124 cilia- and flagella-associated protein 58
      (term hierarchy)
    • InterPro Domains
      IPR049270 Cilia- and flagella-associated protein 58, central coiled coil
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 1
    References
    more
    • Summaries
      All 24
      Diseases 1
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory