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Nsl1 Gene Detail
Summary
  • Symbol
    Nsl1
  • Name
    NSL1, MIS12 kinetochore complex component
  • Synonyms
    4833432M17Rik, LOC381318
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685830
    NCBI Gene: 381318
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:190794710-190816755 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 96.28 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    708 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685830
 protein coding gene Chr1:190794710-190818671 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016938
 protein coding gene Chr1:198083616-198109516 (+)
A/J MGP_AJ_G0016917
 protein coding gene Chr1:189968462-189991864 (+)
AKR/J MGP_AKRJ_G0016882
 protein coding gene Chr1:195586397-195609787 (+)
BALB/cJ MGP_BALBcJ_G0016875
 protein coding gene Chr1:190640299-190663750 (+)
C3H/HeJ MGP_C3HHeJ_G0016699
 protein coding gene Chr1:196438580-196465185 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017338
 protein coding gene Chr1:204395036-204420587 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015045
 protein coding gene Chr1:180867691-180892400 (+)
CAST/EiJ MGP_CASTEiJ_G0016282
 protein coding gene Chr1:196026536-196053397 (+)
CBA/J MGP_CBAJ_G0016673
 protein coding gene Chr1:211959330-211991623 (+)
DBA/2J MGP_DBA2J_G0016779
 protein coding gene Chr1:188688182-188714282 (+)
FVB/NJ MGP_FVBNJ_G0016775
 protein coding gene Chr1:186812449-186835862 (+)
LP/J MGP_LPJ_G0016854
 protein coding gene Chr1:199260482-199283985 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016807
 protein coding gene Chr1:218668109-218711330 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017375
 protein coding gene Chr1:195472391-195496070 (+)
PWK/PhJ MGP_PWKPhJ_G0016069
 protein coding gene Chr1:187969115-187993878 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015845
 protein coding gene Chr1:194471723-194497618 (+)
WSB/EiJ MGP_WSBEiJ_G0016344
 protein coding gene Chr1:195689086-195714817 (+)



Homology
more
  • Human Ortholog
    NSL1, NSL1 component of MIS12 kinetochore complex
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NSL1, NSL1 component of MIS12 kinetochore complex
  • Synonyms
    C1orf48, DC8, MIS14
  • Links
    NCBI Gene ID: 25936
    neXtProt AC: NX_Q96IY1
    UniProt: Q96IY1

  • Chr Location
    1q32.3; chr1:212726153-212791782 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro outgrowth assays show that embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming blastocysts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 381318 NCBI Gene Model | MGI Sequence Detail 22046 C57BL/6J ±  kb
    transcript NM_198654 RefSeq | MGI Sequence Detail 2973 Not Specified  
    polypeptide Q8K305 UniProt | EBI | MGI Sequence Detail 281 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138254, MGI:2684951
    References
    more
    • Summaries
      All 36
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory