Igkv16-104 Gene Detail

Summary

• Symbol
  Igkv16-104
• Name
  immunoglobulin kappa variable 16-104
• Synonyms
  LOC381778

• Feature Type
  gene segment
• IDs
  MGI:2685913
  NCBI Gene: 381778
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr6:68402589-68403056 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 6, 31.17 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  132 from dbSNP Build 142
• Strain Annotations
  17

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685913	gene segment	Chr6:68402559-68403056 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0000125	gene segment	Chr6:68639557-68640054 (+)
A/J	MGP_AJ_G0000116	gene segment	Chr6:65723070-65723567 (+)
AKR/J	MGP_AKRJ_G0000122	gene segment	Chr6:67678634-67679131 (+)
BALB/cJ	MGP_BALBcJ_G0000111	gene segment	Chr6:66006447-66006944 (+)
C3H/HeJ	MGP_C3HHeJ_G0000140	gene segment	Chr6:116496343-116496840 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0000164	gene segment	Chr6:70292108-70292605 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0000122	gene segment	Chr6:68029680-68030180 (+)
CBA/J	MGP_CBAJ_G0000116	gene segment	Chr6:73069357-73069854 (+)
DBA/2J	MGP_DBA2J_G0000111	gene segment	Chr6:65321433-65321930 (+)
FVB/NJ	MGP_FVBNJ_G0000111	gene segment	Chr6:64776685-64777182 (+)
LP/J	MGP_LPJ_G0000128	gene segment	Chr6:68455478-68455975 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0000123	gene segment	Chr6:76815643-76816143 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0000148	gene segment	Chr6:67746959-67747459 (+)
PWK/PhJ	MGP_PWKPhJ_G0000104	gene segment	Chr6:64276024-64276524 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0000081	gene segment	Chr6:67141399-67141896 (+)
WSB/EiJ	MGP_WSBEiJ_G0000121	gene segment	Chr6:68070012-68070509 (+)

Homology

• Human Ortholog
  IGKV1-33, immunoglobulin kappa variable 1-33

• Vertebrate Orthologs
  5

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  IGKV1-33, immunoglobulin kappa variable 1-33
  
• Synonyms
  IGKV133, O18
• Links
  HGNC:5737

  NCBI Gene ID: 28933

  
  
• Chr Location
  2p11.2; chr2:89268001-89268506 (-)  GRCh38

---

• Human Ortholog
  IGKV1-37, immunoglobulin kappa variable 1-37 (non-functional)
  
• Synonyms
  IGKV137, O14
• Links
  HGNC:5739

  NCBI Gene ID: 28931

  UniProt: A0A075B6S9

  
  
• Chr Location
  2p11.2; chr2:89297264-89297785 (-)  GRCh38

---

• Human Ortholog
  IGKV1D-33, immunoglobulin kappa variable 1D-33
  
• Synonyms
  IGKV1D33, O8
• Links
  HGNC:5753

  NCBI Gene ID: 28896

  UniProt: P01593

  
  
• Chr Location
  2p11.2; chr2:89913982-89914545 (+)  GRCh38

---

• Human Ortholog
  IGKV1D-37, immunoglobulin kappa variable 1D-37 (non-functional)
  
• Synonyms
  IGKV1D37, O4
• Links
  HGNC:5755

  NCBI Gene ID: 28894

  UniProt: P0DSN7

  
  
• Chr Location
  2p11.2; chr2:89884740-89885216 (+)  GRCh38

---

• Human Ortholog
  IGKV1OR2-108, immunoglobulin kappa variable 1/OR2-108 (non-functional)
  
• Synonyms
  IGKV1OR2108, IGO1
• Links
  HGNC:5767

  NCBI Gene ID: 28862

  
  
• Chr Location
  2q12-q14; chr2:113406396-113406872 (+)  GRCh38

---

• MGI Vertebrate Homology
  Igkv16-104 stringent orthology
  5 human;1 mouse
  
• HCOP
  vertebrate homology predictions: IGKV1-33, IGKV1-37, IGKV1D-33, IGKV1D-37, IGKV1OR2-108
• Gene Tree
  Igkv16-104
  

Mutations,
Alleles, and
Phenotypes

• Incidental Mutations
  APF
• Find Mice (IMSR)
  4 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  1

Expression

• Assay Results
  706
• cDNA Data
  2

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  28
• RefSeq
  2
• UniProt
  1

• Ensembl
  ENSMUSG00000076522 (Evidence)
• NCBI Gene
  381778

Representative Sequences			Length	Strain/Species
genomic	381778	NCBI Gene Model | MGI Sequence Detail	468	C57BL/6J
transcript	M19911	GenBank | ENA | DDBJ | MGI Sequence Detail	421	BALB/c
polypeptide	A0A0B4J1I1	UniProt | EBI | MGI Sequence Detail	116	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR007110 Immunoglobulin-like domain
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR003599 Immunoglobulin subtype
  IPR050150 Immunoglobulin Variable Light Chain
  IPR013106 Immunoglobulin V-set domain

Molecular
Reagents

• All nucleic 2

  cDNA 2

  
  

  Microarray probesets 1

References

• Summaries
  All 13

  Gene Ontology 1
• Earliest
  J:35042 Kofler R, et al., Molecular analysis of the murine lupus-associated anti-self response: involvement of a large number of heavy and light chain variable region genes. Eur J Immunol. 1987 Jan;17(1):91-5
• Latest
  J:164272 Giudicelli V, et al., IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D256-61

TSS for Igkv16-104:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56923	Chr6:68402551-68402568 (+)	-29 bp