Cracr2a MGI Mouse Gene Detail - MGI:2685919 - calcium release activated channel regulator 2A

Symbol

Cracr2a
Name

calcium release activated channel regulator 2A
Synonyms

Efcab4b, LOC243645, LOC381812

Feature Type

protein coding gene
IDs

MGI:2685919
NCBI Gene: 381812
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr6:127538299-127651197 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 62.39 cM
Mapping Data

1 experiment

SNPs within 2kb

3206 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685919	protein coding gene	Chr6:127538299-127651211 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031315	protein coding gene	Chr6:131086093-131161185 (+)
A/J	MGP_AJ_G0031286	protein coding gene	Chr6:126082783-126151846 (+)
AKR/J	MGP_AKRJ_G0031214	protein coding gene	Chr6:129487331-129556976 (+)
BALB/cJ	MGP_BALBcJ_G0031293	protein coding gene	Chr6:125639608-125709428 (+)
C3H/HeJ	MGP_C3HHeJ_G0031017	protein coding gene	Chr6:129626117-129698000 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031750	protein coding gene	Chr6:134506290-134587065 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028898	protein coding gene	Chr6:123256449-123325909 (+)
CAST/EiJ	MGP_CASTEiJ_G0030398	protein coding gene	Chr6:129847172-129921161 (+)
CBA/J	MGP_CBAJ_G0030978	protein coding gene	Chr6:139667420-139756729 (+)
DBA/2J	MGP_DBA2J_G0031134	protein coding gene	Chr6:124970953-125039897 (+)
FVB/NJ	MGP_FVBNJ_G0031083	protein coding gene	Chr6:123893232-123961886 (+)
LP/J	MGP_LPJ_G0031214	protein coding gene	Chr6:131178420-131253491 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031122	protein coding gene	Chr6:143598785-143670854 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031785	protein coding gene	Chr6:129460869-129533211 (+)
PWK/PhJ	MGP_PWKPhJ_G0030113	protein coding gene	Chr6:123249591-123322016 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029942	protein coding gene	Chr6:127550230-127631638 (+)
WSB/EiJ	MGP_WSBEiJ_G0030483	protein coding gene	Chr6:129825432-129904593 (+)

Human Ortholog

CRACR2A, calcium release activated channel regulator 2A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRACR2A, calcium release activated channel regulator 2A
Synonyms

EFCAB4B, RAB46
Links

HGNC:28657

NCBI Gene ID: 84766

neXtProt AC: NX_Q9BSW2

UniProt: Q9BSW2
Chr Location

12p13.32; chr12:3606633-3764819 (-) GRCh38

MGI Vertebrate Homology

Cracr2a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CRACR2A
Gene Tree

Cracr2a

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available

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All GO Annotations

49
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

738
Tissues

15
cDNA Data

3
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cracr2a

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All Sequences

51
RefSeq

23
UniProt

1
CCDS

CCDS20566.1, CCDS90125.1

Ensembl

ENSMUSG00000061414 (Evidence)
NCBI Gene

381812

			Length	Strain/Species	Flank
genomic	381812	NCBI Gene Model \| MGI Sequence Detail	112899	C57BL/6J	± kb
transcript	NM_001368877	RefSeq \| MGI Sequence Detail	7613	C57BL/6
polypeptide	Q3UP38	UniProt \| EBI \| MGI Sequence Detail	726	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030488 EF-hand calcium-binding domain-containing protein 4B

(term hierarchy)
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR050227 Ras-related protein Rab

IPR001806 Small GTPase

IPR005225 Small GTP-binding protein domain

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All nucleic 3

cDNA 3

Microarray probesets 1

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MGI:2685308

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 7
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:358031 Pedicini L, et al., Rab46: a novel player in mast cell function. Discov Immunol. 2024;3(1):kyad028

TSS for Cracr2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr59036	Chr6:127538170-127538204 (+)	-112 bp
Tssr59037	Chr6:127538275-127538306 (+)	-8 bp
Tssr59038	Chr6:127538310-127538332 (+)	22 bp
Tssr59039	Chr6:127554900-127554901 (+)	16,602 bp
Tssr59040	Chr6:127554908-127554920 (+)	16,615 bp
Tssr59041	Chr6:127554926-127554942 (+)	16,635 bp
Tssr59042	Chr6:127554944-127554963 (+)	16,655 bp
Tssr59043	Chr6:127559086-127559149 (+)	20,819 bp
Tssr59044	Chr6:127559164-127559175 (+)	20,871 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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