About   Help   FAQ
Trim71 Gene Detail
Summary
  • Symbol
    Trim71
  • Name
    tripartite motif-containing 71
  • Synonyms
    2610206G21Rik, 636931, lin-41, Lin41, LOC382112, mlin-41, mLin41
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685973
    NCBI Gene: 636931
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:114340336-114393437 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 64.54 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1452 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685973
 protein coding gene Chr9:114336201-114393437 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035389
 protein coding gene Chr9:116939846-117001056 (-)
A/J MGP_AJ_G0035369
 protein coding gene Chr9:112664867-112722439 (-)
AKR/J MGP_AKRJ_G0035302
 protein coding gene Chr9:115524059-115583584 (-)
BALB/cJ MGP_BALBcJ_G0035365
 protein coding gene Chr9:112462865-112522027 (-)
C3H/HeJ MGP_C3HHeJ_G0035073
 protein coding gene Chr9:116036928-116095730 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035888
 protein coding gene Chr9:120139193-120206341 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032771
 protein coding gene Chr9:109965095-110024480 (-)
CAST/EiJ MGP_CASTEiJ_G0034378
 protein coding gene Chr9:115879241-115939193 (-)
CBA/J MGP_CBAJ_G0035040
 protein coding gene Chr9:124628416-124692212 (-)
DBA/2J MGP_DBA2J_G0035199
 protein coding gene Chr9:112144362-112201597 (-)
FVB/NJ MGP_FVBNJ_G0035146
 protein coding gene Chr9:110955669-111013557 (-)
LP/J MGP_LPJ_G0035278
 protein coding gene Chr9:117287517-117350234 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035187
 protein coding gene Chr9:125874296-125932752 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035907
 protein coding gene Chr9:115898570-115958303 (-)
PWK/PhJ MGP_PWKPhJ_G0034084
 protein coding gene Chr9:112442136-112499654 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033918
 protein coding gene Chr9:115949911-116007923 (-)
WSB/EiJ MGP_WSBEiJ_G0034498
 protein coding gene Chr9:115777653-115837699 (-)



Homology
more
  • Human Ortholog
    TRIM71, tripartite motif containing 71
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM71, tripartite motif containing 71
  • Synonyms
    HYC4, HYDCC1, LIN-41, LIN41
  • Links
    NCBI Gene ID: 131405
    neXtProt AC: NX_Q2Q1W2
    UniProt: Q2Q1W2

  • Chr Location
    3p22.3; chr3:32817997-32897824 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Trim71 mouse models; 1 with human TRIM71 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 6 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous gene trap mutations of this gene result in failure of cranial neural tube closure and embryonic lethality. Homozygotes for a gene trap allele exhibit exencephaly, abnormal nasal process and facial prominence, reduced brain size, and embryonic or fetal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    54
  • cDNA Data
    10
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 636931 NCBI Gene Model | MGI Sequence Detail 53102 C57BL/6J ±  kb
    transcript NM_001042503 RefSeq | MGI Sequence Detail 5197 C57BL/6  
    polypeptide Q1PSW8 UniProt | EBI | MGI Sequence Detail 855 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1919741, MGI:2143176, MGI:3779694
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 9
      Phenotypes 21
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory