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Trim71 Gene Detail
Summary
  • Symbol
    Trim71
  • Name
    tripartite motif-containing 71
  • Synonyms
    2610206G21Rik, 636931, lin-41, Lin41, LOC382112, mlin-41, mLin41
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685973
    NCBI Gene: 636931
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:114340336-114393437 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 64.54 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1452 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685973
 protein coding gene Chr9:114336201-114393437 (-)
129S1/SvImJ ENSMUSG00200027529
 protein coding gene Chr9:111438770-111495997 (-)
A/J ENSMUSG00195032365
 protein coding gene Chr9:110637921-110694952 (-)
AKR/J ENSMUSG00220021980
 protein coding gene Chr9:111100987-111158231 (-)
BALB/cJ ENSMUSG00180025564
 protein coding gene Chr9:111175620-111232660 (-)
C3H/HeJ ENSMUSG00175016654
 protein coding gene Chr9:111396671-111453697 (-)
C57BL/6NJ ENSMUSG00215023925
 protein coding gene Chr9:111281186-111338443 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032771
 protein coding gene Chr9:109965095-110024480 (-)
CAST/EiJ ENSTCUG00005028429
 protein coding gene Chr9:111056497-111113371 (-)
CBA/J ENSMUSG00210028921
 protein coding gene Chr9:111123621-111180837 (-)
DBA/2J ENSMUSG00185014354
 protein coding gene Chr9:111460368-111517579 (-)
FVB/NJ ENSMUSG00205049245
 protein coding gene Chr9:111298335-111355360 (-)
JF1/MsJ ENSUMUG00000044437
 protein coding gene Chr9:111284754-111341836 (-)
LP/J ENSMUSG00230049051
 protein coding gene Chr9:111567530-111624751 (-)
NOD/ShiLtJ ENSMUSG00190045842
 protein coding gene Chr9:111053508-111110724 (-)
NZO/HlLtJ ENSMUSG00225022113
 protein coding gene Chr9:111849078-111906306 (-)
PWK/PhJ ENSLUMG00010029583
 protein coding gene Chr9:111234691-111292772 (-)
SPRET/EiJ ENSMSPG00010019826
 protein coding gene Chr9:112900669-112951108 (-)
WSB/EiJ ENSIUOG00005044983
 protein coding gene Chr9:110513200-110570259 (-)



Homology
more
  • Human Ortholog
    TRIM71, tripartite motif containing 71
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM71, tripartite motif containing 71
  • Synonyms
    HYC4, HYDCC1, LIN-41, LIN41
  • Links
    NCBI Gene ID: 131405
    UniProt: Q2Q1W2

  • Chr Location
    3p22.3; chr3:32817526-32897824 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Trim71 mouse models; 1 with human TRIM71 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 6 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous gene trap mutations of this gene result in failure of cranial neural tube closure and embryonic lethality. Homozygotes for a gene trap allele exhibit exencephaly, abnormal nasal process and facial prominence, reduced brain size, and embryonic or fetal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    75
  • cDNA Data
    10
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 636931 NCBI Gene Model | MGI Sequence Detail 53102 C57BL/6J ±  kb
    transcript NM_001042503 RefSeq | MGI Sequence Detail 5197 C57BL/6  
    polypeptide Q1PSW8 UniProt | EBI | MGI Sequence Detail 855 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 11
      Primer pair 3
      Other 1
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1919741, MGI:2143176, MGI:3779694
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 13
      Phenotypes 25
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:375529 Li XJ, et al., The RNA-binding protein TRIM71 is essential for hearing in humans and mice and times auditory sensory organ development. Proc Natl Acad Sci U S A. 2025 Sep 9;122(36):e2505811122
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory