Gpr25 MGI Mouse Gene Detail - MGI:2686146 - G protein-coupled receptor 25

Symbol

Gpr25
Name

G protein-coupled receptor 25
Synonyms

LOC383563

Feature Type

protein coding gene
IDs

MGI:2686146
NCBI Gene: 383563
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:136187535-136188611 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 59.61 cM
Mapping Data

1 experiment

SNPs within 2kb

111 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2686146	protein coding gene	Chr1:136186652-136188664 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016539	protein coding gene	Chr1:140076513-140077589 (-)
A/J	MGP_AJ_G0016522	protein coding gene	Chr1:134767906-134768982 (-)
AKR/J	MGP_AKRJ_G0016487	protein coding gene	Chr1:138773625-138774701 (-)
BALB/cJ	MGP_BALBcJ_G0016482	protein coding gene	Chr1:135098652-135099728 (-)
C3H/HeJ	MGP_C3HHeJ_G0016308	protein coding gene	Chr1:138868179-138869255 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016943	protein coding gene	Chr1:145094922-145095998 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014654	protein coding gene	Chr1:127876524-127877600 (-)
CAST/EiJ	MGP_CASTEiJ_G0015888	protein coding gene	Chr1:137969443-137970519 (-)
CBA/J	MGP_CBAJ_G0016281	protein coding gene	Chr1:150126222-150127298 (-)
DBA/2J	MGP_DBA2J_G0016387	protein coding gene	Chr1:133761153-133762229 (-)
FVB/NJ	MGP_FVBNJ_G0016386	protein coding gene	Chr1:132410477-132411553 (-)
LP/J	MGP_LPJ_G0016458	protein coding gene	Chr1:141296218-141297294 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016411	protein coding gene	Chr1:155763005-155764081 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016979	protein coding gene	Chr1:138537915-138538991 (-)
PWK/PhJ	MGP_PWKPhJ_G0015674	protein coding gene	Chr1:132811194-132812270 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015461	protein coding gene	Chr1:137530488-137531564 (-)
WSB/EiJ	MGP_WSBEiJ_G0015951	protein coding gene	Chr1:138582348-138583424 (-)

Human Ortholog

GPR25, G protein-coupled receptor 25

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR25, G protein-coupled receptor 25
Links

HGNC:4480

NCBI Gene ID: 2848

neXtProt AC: NX_O00155

UniProt: O00155
Chr Location

1q32.1; chr1:200872981-200874178 (+) GRCh38

MGI Vertebrate Homology

Gpr25 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPR25
Gene Tree

Gpr25

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

4
Radiation induced

1
Genomic Mutations

3 involving Gpr25
Incidental Mutations

CvDC
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

less

All Sequences

25
RefSeq

2
UniProt

1
CCDS

CCDS48381.1

Ensembl

ENSMUSG00000052759 (Evidence)
NCBI Gene

383563

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052759	Ensembl Gene Model \| MGI Sequence Detail	1077	C57BL/6J	± kb
transcript	ENSMUST00000086395	Ensembl \| MGI Sequence Detail	1077	Not Applicable
polypeptide	ENSMUSP00000083583	Ensembl \| MGI Sequence Detail	358	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000001524 probable G-protein coupled receptor 25

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR050119 G-protein coupled receptor 1

IPR000276 G protein-coupled receptor, rhodopsin-like

less

All nucleic 1

cDNA 1

Microarray probesets 1

Summaries

All 22

Gene Ontology 3

Phenotypes 9
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gpr25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13934	Chr1:136188654-136188669 (-)	-51 bp
Tssr13933	Chr1:136188105-136188177 (-)	470 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24