Tg(Rho)1Wbae
Transgene Detail

Summary

• Symbol: Tg(Rho)1Wbae
• Name: transgene insertion 1, Wolfgang Baehr
• MGI ID: MGI:2686794
• Synonyms: VPP
• Transgene: Tg(Rho)1Wbae Location: unknown
• Alliance: Tg(Rho)1Wbae page

Temporal progressive retinal changes in normal and Tg(Rho)1Wbae/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Rho)1Wbae expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rho (MGI:97914)

• Mutation details: The transgenic construct contained a 15 kb genomic fragment encompassing the mouse rhodopsin gene. 3 substitution mutations were engineered in exon 1 (V20G, P23H, and P27L). 6 kb of upstream sequence and 3 kb of downstream sequence were included in the construct. Northern blot analysis showed that both the inserted mutant rhodopsin transcript and the wild-type transcript are present in transgenic mice, indicating that the site of integration is not at the endogenous rhodopsin locus. (J:12791)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:12791 Naash MI, et al., Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene. Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5499-503
• All: 16 reference(s)