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Klhl6 Gene Detail
Summary
  • Symbol
    Klhl6
  • Name
    kelch-like 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2686922
    NCBI Gene: 239743
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:19765242-19801766 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 12.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    981 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686922
 protein coding gene Chr16:19765242-19801787 (-)
129S1/SvImJ ENSMUSG00200043992
 protein coding gene Chr16:16762548-16799105 (-)
A/J ENSMUSG00195033561
 protein coding gene Chr16:16320048-16356600 (-)
AKR/J ENSMUSG00220041516
 protein coding gene Chr16:16637727-16674301 (-)
BALB/cJ ENSMUSG00180032253
 protein coding gene Chr16:16561300-16597858 (-)
C3H/HeJ ENSMUSG00175049146
 protein coding gene Chr16:16706392-16742935 (-)
C57BL/6NJ ENSMUSG00215036771
 protein coding gene Chr16:16427312-16463879 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020569
 protein coding gene Chr16:17123146-17162071 (-)
CAST/EiJ ENSTCUG00005044820
 protein coding gene Chr16:17043995-17087937 (-)
CBA/J ENSMUSG00210038394
 protein coding gene Chr16:16728198-16764748 (-)
DBA/2J ENSMUSG00185028892
 protein coding gene Chr16:16666902-16703452 (-)
FVB/NJ ENSMUSG00205024398
 protein coding gene Chr16:16669398-16705954 (-)
JF1/MsJ ENSUMUG00000033158
 protein coding gene Chr16:16847460-16882967 (-)
LP/J ENSMUSG00230043510
 protein coding gene Chr16:19246243-19282798 (-)
NOD/ShiLtJ ENSMUSG00190048417
 protein coding gene Chr16:16808471-16845027 (-)
NZO/HlLtJ ENSMUSG00225035963
 protein coding gene Chr16:22492040-22528575 (-)
PWK/PhJ ENSLUMG00010045206
 protein coding gene Chr16:16663414-16700450 (-)
SPRET/EiJ ENSMSPG00010044743
 protein coding gene Chr16:16547955-16583203 (-)
WSB/EiJ ENSIUOG00005037136
 protein coding gene Chr16:16858414-16894965 (-)



Homology
more
  • Human Ortholog
    KLHL6, kelch like family member 6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLHL6, kelch like family member 6
  • Links
    NCBI Gene ID: 89857
    UniProt: Q8WZ60

  • Chr Location
    3q27.1; chr3:183487551-183555706 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 12 alleles in 12 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit spleen hypoplasia, defects in mature B-cell subsets with normal pro- and pre-B-cell development, severely impaired antigen-dependent germinal center formation, and reduced memory IgG response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    606
  • Tissues
    5
  • cDNA Data
    24
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 239743 NCBI Gene Model | MGI Sequence Detail 36525 C57BL/6J ±  kb
    transcript NM_001417212 RefSeq | MGI Sequence Detail 2456 C57BL/6  
    polypeptide Q6V595 UniProt | EBI | MGI Sequence Detail 619 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 25

      Microarray probesets 3
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 20
    • Earliest
      J:87056 Gupta-Rossi N, et al., Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells. Mol Immunol. 2003 Mar;39(13):791-9
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory