Inpp5a MGI Mouse Gene Detail - MGI:2686961 - inositol polyphosphate-5-phosphatase A

Symbol

Inpp5a
Name

inositol polyphosphate-5-phosphatase A

Feature Type

protein coding gene
IDs

MGI:2686961
NCBI Gene: 212111
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr7:138969025-139159568 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 84.57 cM
Mapping Data

1 experiment

SNPs within 2kb

4799 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2686961	protein coding gene	Chr7:138969025-139159568 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033150	protein coding gene	Chr7:144407922-144610058 (+)
A/J	MGP_AJ_G0033132	protein coding gene	Chr7:140327784-140525565 (+)
AKR/J	MGP_AKRJ_G0033064	protein coding gene	Chr7:144122214-144331030 (+)
BALB/cJ	MGP_BALBcJ_G0033133	protein coding gene	Chr7:140072721-140267304 (+)
C3H/HeJ	MGP_C3HHeJ_G0032847	protein coding gene	Chr7:143937999-144142376 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033644	protein coding gene	Chr7:149748493-149946896 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030617	protein coding gene	Chr7:141470084-141656827 (+)
CAST/EiJ	MGP_CASTEiJ_G0032177	protein coding gene	Chr7:136224984-136433543 (+)
CBA/J	MGP_CBAJ_G0032820	protein coding gene	Chr7:154795402-155007519 (+)
DBA/2J	MGP_DBA2J_G0032972	protein coding gene	Chr7:138285182-138481301 (+)
FVB/NJ	MGP_FVBNJ_G0032925	protein coding gene	Chr7:138172892-138365466 (+)
LP/J	MGP_LPJ_G0033066	protein coding gene	Chr7:145959931-146159718 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032957	protein coding gene	Chr7:155487492-155698599 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033664	protein coding gene	Chr7:143120300-143321679 (+)
PWK/PhJ	MGP_PWKPhJ_G0031883	protein coding gene	Chr7:131460085-131653001 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031728	protein coding gene	Chr7:129950948-130158523 (+)
WSB/EiJ	MGP_WSBEiJ_G0032288	protein coding gene	Chr7:144042446-144238571 (+)

Human Ortholog

INPP5A, inositol polyphosphate-5-phosphatase A

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INPP5A, inositol polyphosphate-5-phosphatase A
Synonyms

5PTASE
Links

HGNC:6076

NCBI Gene ID: 3632

neXtProt AC: NX_Q14642

UniProt: Q14642
Chr Location

10q26.3; chr10:132537787-132783480 (+) GRCh38

MGI Vertebrate Homology

Inpp5a stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: INPP5A
Gene Tree

Inpp5a

less

Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

1 involving Inpp5a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Most mice homozygous for a gene trapped allele show preweaning lethality, while surviving mice exhibit decreased body size, small cerebellum, and early-onset, slowly progressive Purkinje cell degeneration, gliosis, and ataxia.

less

All GO Annotations

11
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

856
Tissues

113
cDNA Data

12
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase inpp5a, inpp5a.2

less

All Sequences

55
RefSeq

10
UniProt

2
CCDS

CCDS21954.1, CCDS52428.1, CCDS90348.1

Ensembl

ENSMUSG00000025477 (Evidence)
NCBI Gene

212111

			Length	Strain/Species	Flank
genomic	212111	NCBI Gene Model \| MGI Sequence Detail	190544	C57BL/6J	± kb
transcript	NM_001127363	RefSeq \| MGI Sequence Detail	2843	C57BL/6
polypeptide	Q7TNC9	UniProt \| EBI \| MGI Sequence Detail	412	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000009047 inositol polyphosphate-5-phosphatase A

(term hierarchy)
EC

3.1.3.56
InterPro Domains

IPR036691 Endonuclease/exonuclease/phosphatase superfamily

IPR000300 Inositol polyphosphate-related phosphatase

IPR039737 Type I inositol 1,4,5-trisphosphate 5-phosphatase

less

All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 4

Summaries

All 39

Developmental Gene Expression 6

Gene Ontology 7

Phenotypes 11
Earliest

J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Inpp5a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69718	Chr7:138968988-138969077 (+)	8 bp
Tssr69719	Chr7:138969241-138969250 (+)	221 bp
Tssr69720	Chr7:138980421-138980444 (+)	11,408 bp
Tssr69721	Chr7:138983663-138983681 (+)	14,647 bp
Tssr69722	Chr7:138983701-138983720 (+)	14,686 bp
Tssr69723	Chr7:138990211-138990215 (+)	21,188 bp
Tssr69724	Chr7:139049630-139049641 (+)	80,611 bp
Tssr69725	Chr7:139062306-139062308 (+)	93,282 bp
Tssr69726	Chr7:139105643-139105646 (+)	136,620 bp
Tssr69727	Chr7:139118027-139118055 (+)	149,016 bp
Tssr69728	Chr7:139132854-139132870 (+)	163,837 bp
Tssr69729	Chr7:139132937-139132950 (+)	163,919 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24