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S100a7a Gene Detail
Summary
  • Symbol
    S100a7a
  • Name
    S100 calcium binding protein A7A
  • Synonyms
    LOC381493, S100a15, S100a17l1, S100A7f
  • Feature Type
    protein coding gene
  • IDs
    MGI:2687194
    NCBI Gene: 381493
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:90561609-90565437 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.82 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2687194
 protein coding gene Chr3:90561324-90565976 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027478
 protein coding gene Chr3:90989789-90994186 (+)
A/J MGP_AJ_G0027442
 protein coding gene Chr3:87951402-87955881 (+)
AKR/J MGP_AKRJ_G0027407
 protein coding gene Chr3:90116856-90121214 (+)
BALB/cJ MGP_BALBcJ_G0027451
 protein coding gene Chr3:87908153-87912699 (+)
C3H/HeJ MGP_C3HHeJ_G0027193
 protein coding gene Chr3:90279504-90283870 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027897
 protein coding gene Chr3:94396364-94400727 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025250
 protein coding gene Chr3:83453757-83457971 (+)
CAST/EiJ MGP_CASTEiJ_G0026639
 protein coding gene Chr3:90679559-90684725 (+)
CBA/J MGP_CBAJ_G0027168
 protein coding gene Chr3:97599324-97603682 (+)
DBA/2J MGP_DBA2J_G0027305
 protein coding gene Chr3:87319196-87323554 (+)
FVB/NJ MGP_FVBNJ_G0027273
 protein coding gene Chr3:85646675-85651090 (+)
LP/J MGP_LPJ_G0027414
 protein coding gene Chr3:92047821-92053150 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027294
 protein coding gene Chr3:103851443-103855800 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027956
 protein coding gene Chr3:89866243-89870601 (+)
PWK/PhJ MGP_PWKPhJ_G0026373
 protein coding gene Chr3:87217032-87221524 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026193
 protein coding gene Chr3:89056955-89065447 (+)
WSB/EiJ MGP_WSBEiJ_G0026721
 protein coding gene Chr3:90271592-90277220 (+)



Homology
more
  • Human Ortholog
    S100A7, S100 calcium binding protein A7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    S100A7, S100 calcium binding protein A7
  • Synonyms
    PSOR1, S100A7c
  • Links
    NCBI Gene ID: 6278
    neXtProt AC: NX_P31151
    UniProt: P31151

  • Chr Location
    1q21.3; chr1:153457744-153460651 (-)  GRCh38
  • Human Ortholog
    S100A7A, S100 calcium binding protein A7A
  • Synonyms
    NICE-2, NICE2, S100A15, S100A7f, S100A7L1
  • Links
    NCBI Gene ID: 338324
    neXtProt AC: NX_Q86SG5
    UniProt: Q86SG5

  • Chr Location
    1q21.3; chr1:153416520-153423222 (+)  GRCh38
  • Human Ortholog
    S100A7L2, S100 calcium binding protein A7 like 2
  • Synonyms
    S100a7b
  • Links
    NCBI Gene ID: 645922
    UniProt: Q5SY68

  • Chr Location
    1q21.3; chr1:153437058-153438347 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with S100a7a mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Radiation induced
    1
  • Targeted
    2
  • Transgenic
    1
  • Genomic Mutations
    2 involving S100a7a
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    9 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    7
  • cDNA Data
    5
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 381493 NCBI Gene Model | MGI Sequence Detail 3829 C57BL/6J ±  kb
transcript NM_199422 RefSeq | MGI Sequence Detail 741 C57BL/6xC3H*  
polypeptide Q6S5I3 UniProt | EBI | MGI Sequence Detail 108 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 1
Other
Accession IDs
less
MGI:2685866
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Diseases 2
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:344627 Harrison SA, et al., Comparative analysis of the physical properties of murine and human S100A7: Insight into why zinc piracy is mediated by human but not murine S100A7. J Biol Chem. 2023 Sep 26;299(11):105292
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory